Uric Acid Test ### By Harib Diagnostic Lab

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Uric Acid Test ### By Harib Diagnostic Lab
Uric Acid Test ### By Harib Diagnosti...

URIC ACID TEST,
Uric acid is a heterocyclic compound of carbon, nitrogen, oxygen, and hydrogen with the formula C5H4N4O3. It forms ions and salts known as urates and acid urates, such as ammonium acid urate.
Uric acid is a product of the metabolic breakdown of purine nucleotides, and it is a normal component of urine.
High blood concentrations of uric acid can lead to gout and are associated with other medical conditions, including diabetes and the formation of ammonium acid urate kidney stones.

High uric acid
Hyperuricemia (high levels of uric acid), which induces gout, has various potential origins:
Diet may be a factor. High intake of dietary purine, high-fructose corn syrup, and table sugar can increase levels of uric acid.
Serum uric acid can be elevated by reduced excretion via the kidneys.
Fasting or rapid weight loss can temporarily elevate uric acid levels.
Certain drugs, such as thiazide diuretics, can increase blood uric acid levels by interfering with renal clearance.
Tumor lysis syndrome, a metabolic complication of cancers or chemotherapy, due to nucleobase and potassium release into the plasma.

Gout
Excess blood uric acid can induce gout, a painful condition resulting from needle-like crystals of uric acid precipitating in joints, capillaries, skin, and other tissues. Gout can occur where serum uric acid levels are as low as 6 mg per 100 ml (357 µmol/l), but an individual can have serum values as high as 9.6 mg per 100 ml (565 µmol/l) and not have gout.

In humans, purines are metabolized into uric acid which is then excreted in the urine. Consumption of some types of purine-rich foods, particularly meat and seafood, increases gout risk. such as liver, kidney, and sweetbreads, and certain types of seafood including anchovies, herring, sardines, mussels, scallops, trout, haddock, mackerel and tuna. Moderate intake of purine-rich vegetables, however, is not associated with an increased risk of gout.

Low uric acid
Low uric acid (hypouricemia) can have numerous causes. Low dietary zinc intakes cause lower uric acid levels. This effect can be even more pronounced in women oral contraceptive medication. Sevelamer,  drug indicated for prevention of hyperphosphataemia in people with chronic kidney failure, can significantly reduce serum uric acid.

Normalizing low uric acid
Correcting low or deficient zinc levels can help elevate serum uric acid.


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