Neuroinflammation in Alzheimer's Disease: How is Amyloid Detected by Microglia?

Identify the pattern recognition receptors (PRRs) involved in detecting amyloid in the context of Alzheimer's disease.
Summarize the research by Stewart et al. that elucidates the roles of CD36, TLR4, and TLR6 in Alzheimer's disease.
Describe how activation of CD36, TLR4, and TLR6 leads to the release of prostaglandins and cytokines in Alzheimer's disease.
Discuss the hypothesis of amyloid as a potential pathogen-associated molecular pattern (PAMP) and its implications in Alzheimer's disease.
Define pyroptosis, a form of programmed cell death, and its relevance in the context of Alzheimer's disease.
Explain the NLRP3 activation pathway, a key component of the innate immune response, in the context of amyloid-associated neuroinflammation in Alzheimer's disease.
Describe the research paper by Heneka et al. that establishes a link between NLRP3 and Alzheimer's disease, including its findings and implications.
Analyze how the research by Stewart et al. and Heneka et al. contribute to our understanding of the role of PRRs, CD36, TLR4, TLR6, and NLRP3 in the pathogenesis of Alzheimer's disease, and their potential as therapeutic targets.