The brain is immune privileged: What does that mean?

Develop a comprehensive understanding of Peter Medawar's experiments on rejection in the peripheral compared to the brain.

Describe the concept of immune privilege in detail, including its definition and implications for the brain and other parts of the body.

Analyze the complex signaling mechanisms involved in the interaction between microglia and the peripheral immune system, including the release of cytokines and other signaling molecules.

Demonstrate an understanding of the unique immunology of the brain, including the roles of the skull bone marrow, and brain meninges immune cells, and how they contribute to the overall immune system.