Aptamers: Structure, SELEX selection, Advantages, Disadvantages and Applications

This video explains about Aptamers: Structure, SELEX selection, Advantages, Disadvantages and Applications.

Aptamers are oligonucleotides, having high affinity and specificity in identifying the target molecules. The word aptamer is derived from the latin. “aptus means fit” and greek “meros means part”.

Aptamers are single-stranded RNA or DNA oligonucleotides, 15 to 60 bases in length that bind with high affinity to specific molecular targets; most aptamers to proteins bind with equilibrium constant in the range of 1 pico Molar  to 1 nano Molar, similar to monoclonal antibodies.

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