Class (03) = Shikimic Acid Pathway (Part 02) | Shikimic Acid Pathway Steps with Chemical Reaction
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The shikimic acid pathway is a metabolic pathway for the biosynthesis of aromatic amino acids (phenylalanine, tyrosine and tryptophan).The shikmic acid is a key intermediate from carbohydrate for the biosynthesis of C6-C3 units (phenyl propane derivative).
The seven enzymes involved in the shikimate pathway are DAHP synthase, 3-dehydroquinate synthase, 3-dehydroquinate dehydratase, shikimate dehydrogenase, shikimate kinase, EPSP synthase, and chorismate synthase. The pathway starts with two substrates, phosphoenol pyruvate and erythrose-4-phosphate and ends with chorismate, a substrate for the three aromatic amino acids.
1. The pathway starts with two substrates, phosphoenol pyruvate and erythrose-4-phosphate and ends with chorismate, a substrate for the three aromatic amino acids.
3. The fifth enzyme involved is the shikimate kinase, an enzyme that catalyzes the ATP-dependent phosphorylation of shikimate to form shikimate 3-phosphate (shown in the figure below).
4. Shikimate 3-phosphate is then coupled with phosphoenol pyruvate to give 5-enolpyruvylshikimate-3-phosphate via the enzyme 5-enolpyruvylshikimate-3-phosphate (EPSP) synthase.
Then 5-enolpyruvylshikimate-3-phosphate is transformed into chorismate by a chorismate synthase. Prephenic acid is then synthesized by a Claisen rearrangement of chorismate by chorismate mutase.
Prephenate is oxidatively decarboxylated with retention of the hydroxyl group to give p-hydroxyphenylpyruvate, which is transaminated using glutamate as the nitrogen source to give tyrosine and α-ketoglutarate. The prephanic acid undergo aromatization to synthesize Phenylpyruvic acid followed by reductive amination to form Phenylalanine.
The anthranilic acid from chorismic acid extended to form phosphoribosylanthranilic aicd. Later in conjugation with serine in presence of tryptophan synthase it converts to aromatic acid tryptophan.
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How to Download Notes in PDF from Sol... Using Mobile How to Download PDF from Solution Pha...
Free Model Question Paper for Pharmacognosy & Phytochemistry- II (5th Semester- All Units) – https://drive.google.com/drive/folder...
Introduction to Shikimic Acid Pathway by Solution Pharmacy in Hindi Class (02) = Shikimic Acid Pathway (P...
Free Pharmacognosy & Phytochmistry-II Notes- (5th Semester) https://drive.google.com/drive/folder...
The shikimic acid pathway is a metabolic pathway for the biosynthesis of aromatic amino acids (phenylalanine, tyrosine and tryptophan).The shikmic acid is a key intermediate from carbohydrate for the biosynthesis of C6-C3 units (phenyl propane derivative).
The seven enzymes involved in the shikimate pathway are DAHP synthase, 3-dehydroquinate synthase, 3-dehydroquinate dehydratase, shikimate dehydrogenase, shikimate kinase, EPSP synthase, and chorismate synthase. The pathway starts with two substrates, phosphoenol pyruvate and erythrose-4-phosphate and ends with chorismate, a substrate for the three aromatic amino acids.
1. The pathway starts with two substrates, phosphoenol pyruvate and erythrose-4-phosphate and ends with chorismate, a substrate for the three aromatic amino acids.
3. The fifth enzyme involved is the shikimate kinase, an enzyme that catalyzes the ATP-dependent phosphorylation of shikimate to form shikimate 3-phosphate (shown in the figure below).
4. Shikimate 3-phosphate is then coupled with phosphoenol pyruvate to give 5-enolpyruvylshikimate-3-phosphate via the enzyme 5-enolpyruvylshikimate-3-phosphate (EPSP) synthase.
Then 5-enolpyruvylshikimate-3-phosphate is transformed into chorismate by a chorismate synthase. Prephenic acid is then synthesized by a Claisen rearrangement of chorismate by chorismate mutase.
Prephenate is oxidatively decarboxylated with retention of the hydroxyl group to give p-hydroxyphenylpyruvate, which is transaminated using glutamate as the nitrogen source to give tyrosine and α-ketoglutarate. The prephanic acid undergo aromatization to synthesize Phenylpyruvic acid followed by reductive amination to form Phenylalanine.
The anthranilic acid from chorismic acid extended to form phosphoribosylanthranilic aicd. Later in conjugation with serine in presence of tryptophan synthase it converts to aromatic acid tryptophan.
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Facebook Group- Facebook: solutionpharamcy
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New channel (Pharmacy Dictionary) - @pharmacydictionary
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#solutionpharmacy #Pharmacologyclass #GPATonlinetest
5 سال پیش
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