Q & A: How do T-cells recognize antigens?

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85.6 هزار بار بازدید - 7 سال پیش - #immunology
#immunology #pathology #antigenrecognition

Q: How do T-cells recognize antigens?

A: T lymphocytes cannot directly recognize or be activated by antigens on microbes or those that are extra-cellular in circulation. They are rather programmed to be able to recognize antigens that are presented to it by antigen presenting cells like B lymphocytes, macrophages, dendritic cells or other nucleated cells. Very specifically, T-cells require peptides derived from these antigens to be presented along with certain cell surface molecules called MHC molecules.

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References and further reading:
💡Kumar V, Abbas AK, Fausto N, Aster JC. Robbins Basic Pathology. 10th ed. Elsevier; 2018.
💡Kumar V, Abbas AK, Fausto N, Aster JC. Robbins and Cotran – Pathologic Basis of Disease. 8th Edition. Saunders Elsevier; 2010.
💡Abbas AK, Litchman AH, Pillai S. Cellular and Molecular Immunology. 8th Edition. Saunders Elsevier; 2015.

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7 سال پیش در تاریخ 1396/06/03 منتشر شده است.
85,605 بـار بازدید شده
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