Edmund Neo: Application of ProPresent® Antigen Presentation Assay to Assess Immunogenicity

ProPresent® is ProImmune’s MHC-associated peptide proteomics (MAPPS) assay. It lets you directly identify the peptides which are presented by antigen-presenting cells to T cells. Our core assay has a turnaround time of just 3-4 weeks. ProPresent® tells you exactly which epitopes from your biotherapeutic drug or other protein of interest are presented by HLA molecules to T cells. Peptides are identified by the classical method of HLA-peptide complex extraction, peptide elution and subsequent peptide epitope identification by sequencing mass spectrometry. ProPresent® can be used to identify the peptides associated with HLA-DR, DP or DQ, and with HLA Class I.  Combined with ProImmune’s REVEAL® HLA-peptide binding assays and functional T cell assays, ProPresent completes the picture in understanding the potential immunogenicity of your compounds.

Edmund Neo is ProImmune’s Immunology Sales Manager based in Singapore representing the company in the Asia-Pacific Region. Edmund graduated from the National University of Singapore and worked with Abbott Laboratories researching on the impact of mineral fortification on the aggregation of dairy proteins before joining ProImmune in 2019. He has played a pivotal role in the team supporting customers in both academia and corporate spaces across his region to achieve their research objectives.