Bacteriophages - Deadly Virus, or Superbug Solution?

In this video, you will learn about the deadliest organism in the world, bacteriophages, and how they might be the solution to one of humanities greatest medical challenges, antibiotic resistant bacteria. This video will describe what bacteriophages and superbugs are, and then look closer at the functions of bacteriophages, how they interact with our cells and bacterial cells, how bacteriophage treatment is done and can cure serious infections, and finally some limitations of the technology. While doctors and medical researchers have been puzzled by superbugs in the past, this new promising technology might be the solution that we’ve been looking for. With new research, bacteria may be reduced to an afterthought when thinking of dangers to humanity. Introduction: 0:00 What are Superbugs, why are they Dangerous?: 0:45 What are Bacteriophages?: 1:27 How do bacteriophages interact with humans and bacteria?: 2:09 How is bacteriophage treatment done?: 2:45 Current treatment methods: 3:28 Limitations of bacteriophages: 4:04 Can bacteriophages enhance current treatment practices?: 5:31 Conclusion: 6:06 This video was made by McMaster University students Thirumagal Gowrikanthan, Zunaira Ahmad, Cameron Walters, and Runisan Natheeswaran in collaboration with the Demystifying Research McMaster Program. The video uses background music titled “Over The Ocean” by e s c p from free-stock-music. This video is provided for general and educational information only. Copyright McMaster University 2023 References: Baral, B. (2023, January 24). Phages against Killer superbugs: An enticing strategy against antibiotics-resistant pathogens. Frontiers in pharmacology. https:// www.ncbi.nlm.nih.gov/pmc/articles/PMC9902939/ #:~:text=Because%20of%20their%20ability%20to,antibiotics%20in%20treating%20bact erial%20infections Ellis, D. (2023, August 22). New powerful antibiotic isolated from bacteria could combat multiresistant “superbugs.”Medical News. www.news-medical.net/news/20230822/ New-powerful-antibiotic-isolated-from-bacteria-could-combat-multi-resistantsuperbugs.aspx Iftikhar, N. (2019, January 14). Phage therapy: How it works, pros and cons, availability, and more. Healthline. www.healthline.com/health/phage-therapy#legality-i… Kurzgesagt. (2018, May 13). The deadliest being on Planet Earth – the bacteriophage. YouTube.    • The Deadliest Being on Planet Earth –...   Lecrubier, A. (2023, September 15). New antibiotic could combat multidrug-resistant superbugs. Medscape. www.medscape.com/viewarticle/996504#?form=fpf Principi, N., Silvestri, E., & Esposito, S. (2019, April 24). Advantages and limitations of bacteriophages for the treatment of bacterial infections. Frontiers. https:// www.frontiersin.org/articles/10.3389/fphar.2019.00513/full Superbugs, what they are and why they may be the new pandemic. Iberdrola. (n.d.). https:// www.iberdrola.com/innovation/ superbugs#:~:text=Superbugs%20are%20caused%20by%20the,in%20an%20attempt%2 0to%20survive U.S. Department of Health and Human Services. (2019, October 28). Stop the spread of Superbugs. National Institutes of Health. newsinhealth.nih.gov/2014/02/stopspreadsuperbugs#:… Prevention%20(CDC) What is phage therapy?. UC San Diego School of Medicine. (n.d.). medschool.ucsd.edu/ som/medicine/divisions/idgph/research/center-innovative-phage-applications-andtherapeutics/patient-care/Pages/ default.aspx#:~:text=They%20are%20the%20most%20common,a%20life%20from%20a n%20infection

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