AIRR-C Seminar Series, September 28, 2023 - Pieter Meysman, University of Antwerp, Belgium
1.6 هزار بار بازدید -
10 ماه پیش
-
On the application of TCR-epitope
On the application of TCR-epitope prediction models
Established Speaker: Pieter Meysman, University of Antwerp, Belgium
Talk abstract
The recognition of a T-cell epitope target is driven by the unique sequence of the T-cell receptor (TCR). As the TCR sequence theoretically contains all the information that determines its target, it must be possible to infer its target from this sequence. Indeed, within specific settings, we now have performant machine learning models that can address this challenge. It has therefore become necessary to start considering how we can apply these models to gain novel immunological understanding.
In this talk, I want to focus on the application of TCR-epitope prediction models to identify epitope-specific T-cells in full repertoire data, and the additional challenges that are often missed by current evaluation efforts. I also aim to highlight the biggest advancements and milestones that we can expect in the coming years in the field, especially in regard to the unseen epitope prediction problem.
Speaker Bio
Prof. Pieter Meysman is an associate professor at the University of Antwerp at the ADREM data lab and leads the immunoinformatics activities of the AUDACIS consortium. He graduated as a PhD in bioscience engineering from the KULeuven in 2012, and has published more than 80 research articles and patents. In addition to his academic research, he is part-time CTO of ImmuneWatch, an AI company aiming to decode the T-cell receptor repertoire.
His main research focus is on the use of artificial intelligence to gain understanding into the adaptive immune system. To this end, he has supervised the development of several immunoinformatics tools to link T-cell receptors to their (seen or unseen) targets, including TCRex, ClusTCR and ImRex. He has won a number of awards for his research into the human T-cell receptor repertoire, including most recently the GSK Vaccines award.
AIRR-C Seminar Series website: https://www.antibodysociety.org/the-a...
Established Speaker: Pieter Meysman, University of Antwerp, Belgium
Talk abstract
The recognition of a T-cell epitope target is driven by the unique sequence of the T-cell receptor (TCR). As the TCR sequence theoretically contains all the information that determines its target, it must be possible to infer its target from this sequence. Indeed, within specific settings, we now have performant machine learning models that can address this challenge. It has therefore become necessary to start considering how we can apply these models to gain novel immunological understanding.
In this talk, I want to focus on the application of TCR-epitope prediction models to identify epitope-specific T-cells in full repertoire data, and the additional challenges that are often missed by current evaluation efforts. I also aim to highlight the biggest advancements and milestones that we can expect in the coming years in the field, especially in regard to the unseen epitope prediction problem.
Speaker Bio
Prof. Pieter Meysman is an associate professor at the University of Antwerp at the ADREM data lab and leads the immunoinformatics activities of the AUDACIS consortium. He graduated as a PhD in bioscience engineering from the KULeuven in 2012, and has published more than 80 research articles and patents. In addition to his academic research, he is part-time CTO of ImmuneWatch, an AI company aiming to decode the T-cell receptor repertoire.
His main research focus is on the use of artificial intelligence to gain understanding into the adaptive immune system. To this end, he has supervised the development of several immunoinformatics tools to link T-cell receptors to their (seen or unseen) targets, including TCRex, ClusTCR and ImRex. He has won a number of awards for his research into the human T-cell receptor repertoire, including most recently the GSK Vaccines award.
AIRR-C Seminar Series website: https://www.antibodysociety.org/the-a...
10 ماه پیش
در تاریخ 1402/07/09 منتشر شده
است.
1,678
بـار بازدید شده