AIRR-C Seminar Series, June 29, 2023 - Ellen Shrock, Harvard University, USA
752 بار بازدید -
12 ماه پیش
-
Germline-encoded amino acid–binding motifs drive
Germline-encoded amino acid–binding motifs drive immunodominant public antibody responses
Early Career Speaker: Ellen Shrock, Harvard University, USA
Talk Abstract
Despite the vast diversity of the antibody repertoire, infected individuals often mount antibody responses to precisely the same epitopes within antigens. The immunological mechanisms underpinning this phenomenon remain unknown. By mapping 376 immunodominant “public epitopes” at high resolution and characterizing several of their cognate antibodies, we concluded that germline-encoded sequences in antibodies drive recurrent recognition. Systematic analysis of antibody-antigen structures uncovered 18 human and 21 partially overlapping mouse germline-encoded amino acid–binding (GRAB) motifs within heavy and light V gene segments that in case studies proved critical for public epitope recognition. GRAB motifs represent a fundamental component of the immune system’s architecture that promotes recognition of pathogens and leads to species-specific public antibody responses that can exert selective pressure on pathogens.
Speaker Bio
Ellen Shrock received her Ph.D. in Biological and Biomedical Sciences from Harvard University, where she worked in the laboratory of Prof. Stephen Elledge using high-throughput profiling techniques to study the human antibody response to viruses and the mechanisms underlying antigen immunodominance. Ellen received her A.B. in Integrative Biology from Harvard College, where she conducted research with Prof. George Church on genome editing for porcine-to-human xenotransplantation and on the assembly of a synthetic, radically recoded E. coli genome.
AIRR-C Seminar Series website: https://www.antibodysociety.org/the-a...
Early Career Speaker: Ellen Shrock, Harvard University, USA
Talk Abstract
Despite the vast diversity of the antibody repertoire, infected individuals often mount antibody responses to precisely the same epitopes within antigens. The immunological mechanisms underpinning this phenomenon remain unknown. By mapping 376 immunodominant “public epitopes” at high resolution and characterizing several of their cognate antibodies, we concluded that germline-encoded sequences in antibodies drive recurrent recognition. Systematic analysis of antibody-antigen structures uncovered 18 human and 21 partially overlapping mouse germline-encoded amino acid–binding (GRAB) motifs within heavy and light V gene segments that in case studies proved critical for public epitope recognition. GRAB motifs represent a fundamental component of the immune system’s architecture that promotes recognition of pathogens and leads to species-specific public antibody responses that can exert selective pressure on pathogens.
Speaker Bio
Ellen Shrock received her Ph.D. in Biological and Biomedical Sciences from Harvard University, where she worked in the laboratory of Prof. Stephen Elledge using high-throughput profiling techniques to study the human antibody response to viruses and the mechanisms underlying antigen immunodominance. Ellen received her A.B. in Integrative Biology from Harvard College, where she conducted research with Prof. George Church on genome editing for porcine-to-human xenotransplantation and on the assembly of a synthetic, radically recoded E. coli genome.
AIRR-C Seminar Series website: https://www.antibodysociety.org/the-a...
12 ماه پیش
در تاریخ 1402/04/26 منتشر شده
است.
752
بـار بازدید شده