Levodopa, Carbidopa Mnemonic for USMLE
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4 سال پیش
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Levodopa and Carbidopa are drugs used in the treatment of Parkinson's disease. Levodopa is a pharmacologic form of L-DOPA, a precursor to dopamine. Levodopa can cross the blood brain barrier, after which it is converted into dopamine. This increase in dopamine in the brain helps stimulate motor control of body movements, treating Parkinson’s disease.
In contrast, carbidopa works by blocking or inhibiting the enzyme DOPA decarboxylase, thereby preventing the conversion of L-DOPA into dopamine. Since Carbidopa cannot cross the blood brain barrier, it only works peripherally. When given in conjunction with Levodopa, carbidopa reduces peripheral conversion of dopamine and increases the availability of central L-DOPA.
Side effects of levodopa are mainly caused by its peripheral conversion into dopamine, leading to nausea and vomiting, as well as arrhythmias and hypotension. These peripheral effects can be largely minimized by the use of carbidopa. Other adverse effects of levodopa are central effects of dopamine, including anxiety, agitation, and hallucinations. Since these are central effects, they do not respond to carbidopa use.
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Study interactive image: https://pixorize.com/view/6482
#USMLE #Step1 #Pharm #levodopa #carbidopa #parkinsons
Levodopa and Carbidopa are drugs used in the treatment of Parkinson's disease. Levodopa is a pharmacologic form of L-DOPA, a precursor to dopamine. Levodopa can cross the blood brain barrier, after which it is converted into dopamine. This increase in dopamine in the brain helps stimulate motor control of body movements, treating Parkinson’s disease.
In contrast, carbidopa works by blocking or inhibiting the enzyme DOPA decarboxylase, thereby preventing the conversion of L-DOPA into dopamine. Since Carbidopa cannot cross the blood brain barrier, it only works peripherally. When given in conjunction with Levodopa, carbidopa reduces peripheral conversion of dopamine and increases the availability of central L-DOPA.
Side effects of levodopa are mainly caused by its peripheral conversion into dopamine, leading to nausea and vomiting, as well as arrhythmias and hypotension. These peripheral effects can be largely minimized by the use of carbidopa. Other adverse effects of levodopa are central effects of dopamine, including anxiety, agitation, and hallucinations. Since these are central effects, they do not respond to carbidopa use.
Subscribe for more: https://bit.ly/2yybxhm
Study interactive image: https://pixorize.com/view/6482
#USMLE #Step1 #Pharm #levodopa #carbidopa #parkinsons
4 سال پیش
در تاریخ 1399/11/01 منتشر شده
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