DPP-4 Inhibitors Mnemonic for Medicine & USMLE

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DPP-4 inhibitors are a class of drugs recognizable by their -gliptin ending, including sitagliptin, linagliptin, and saxagliptin. These drugs are used to treat type 2 diabetes mellitus by lowering blood sugar levels. Inhibition of the DPP-4 enzyme has several downstream effects, including increasing GLP-1 levels, decreasing gastric emptying and increasing satiety. These drugs also stimulate glucose-dependent insulin release, and decrease glucagon release. Side effects of these drugs include an increased risk of developing urinary infections and upper respiratory infections. Notably, these drugs typically do not cause hypoglycemia, and usually have no effect on weight in patients.

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