Halothane fluothane, halothane, halothane anesthesia, halothane structure, halothane properties,

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Halothane, sold under the brand name Fluothane among others, is a general anaesthetic. It can be used to start or maintain anaesthesia. One of its benefits is that it does not increase the production of saliva, which can be particularly useful in those who are difficult to intubate. It is given by inhalation.

Formula: C2HBrClF3
Boiling point: 50.2 °C
Molar mass: 197.381 g/mol
CAS ID: 151-67-7
Metabolism: Hepatic (CYP2E1)
Excretion: kidney, respiratory

Halothane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It reduces the blood pressure and frequently decreases the pulse rate and depresses respiration. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability.

Vapor pressure
243 mm Hg
Halothane has a vapor pressure of 243 mm Hg (at 20° C), a blood/gas partition coefficient of 2.3, and a fat/blood coefficient of 51. Because of high solubility in fat, its clearance from the body is slower than other agents.

Moa
Halothane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It reduces the blood pressure and frequently decreases the pulse rate and depresses respiration. ... Halothane's effect are also likely due to binding to NMDA and calcium channels, causing hyperpolarization.

Solubility
Since halothane is very soluble in oil and quite insoluble in water (Steward et al., 1973), these are presumably hydrophobic sites, the bound halothane molecules being stabilized by hydrophobic interactions.

Caffeine
The caffeine halothane contracture test (CHCT) is the criterion standard for establishing the diagnosis of malignant hyperthermia (MH). The test is performed on freshly biopsied muscle tissue at 30 centers worldwide; one of these centers is located in Canada, and four are located in the United States

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