Vitamin C / ascorbic acid: Sources, Daily requirement, Functions, and Deficiency || Usmle
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📌𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦 :-
📌𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦 :-
Instagram: drgbhanuprakash
Vitamin C / ascorbic acid: Sources, Daily requirement, Functions, and Deficiency manifestations
Ascorbate. Water-soluble, cofactor for enzymatic reactions
• Anti-oxidant properties, guards against oxidative stress
• Vit C serves as a cofactor for prolyl-4-hydroxylase and lysyl hydroxylase, an enzyme involved in collagen synthesis.
• Stable collagen cannot form without proline and lysine hydroxylation. This hydroxylation takes place in the ER.
• Hydroxylation of proline secures the collagen chains in triple-helix formation.
• The subsequent hydroxylation of lysine is required for cross-linking.
• Deficiency of lysyl hydroxylase: Ehlers-Danlos Syndrome Type 6
Other roles:
Cofactor for dopamine hydroxylase (dopamine → norepinephrine)
Required for reduction of iron from Fe3+ → Fe2+, allowing absorption in the duodenum.
Deficiency → scurvy.
Instagram: drgbhanuprakash
Vitamin C / ascorbic acid: Sources, Daily requirement, Functions, and Deficiency manifestations
Ascorbate. Water-soluble, cofactor for enzymatic reactions
• Anti-oxidant properties, guards against oxidative stress
• Vit C serves as a cofactor for prolyl-4-hydroxylase and lysyl hydroxylase, an enzyme involved in collagen synthesis.
• Stable collagen cannot form without proline and lysine hydroxylation. This hydroxylation takes place in the ER.
• Hydroxylation of proline secures the collagen chains in triple-helix formation.
• The subsequent hydroxylation of lysine is required for cross-linking.
• Deficiency of lysyl hydroxylase: Ehlers-Danlos Syndrome Type 6
Other roles:
Cofactor for dopamine hydroxylase (dopamine → norepinephrine)
Required for reduction of iron from Fe3+ → Fe2+, allowing absorption in the duodenum.
Deficiency → scurvy.
4 سال پیش
در تاریخ 1400/01/16 منتشر شده
است.
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