Linfocitos T (Introducción y maduración)

T cells use their TCR receptors to bind to the Major Histocompatibility complex (MHC) and check if it presents any foreign antigen. In this video, we review the development process of T cells, from their stem cell stage until their differentiation into T cells in the thymus.


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📚 SOURCES:
- Alberts B, Johnson A, Lewis J, et al. Molecular Biology of the Cell. 5º ed. New York: Garland Science; (2008). Disponible en: https://www.ncbi.nlm.nih.gov/books/NB...
- Abbas, A. K., Lichtman A.H., Shiv, P. (2010). Inmunología Celular y Molecular. 6º ed. Elsevier
- Murphy, K., Travers, P., Walport M., and Janeway, C. (2016). Janeway's immunobiology. 9º ed. New York: Garland Science
- Mason, D. (1994) Allelic exclusion of alpha chains in TCRs. Int Immunol. 1994 Jun;6(6):881-5. doi: 10.1093/intimm/6.6.881
+ my uni notes

🎬 COPYRIGHT
This video is original and belongs to Víctor Cilleros.


-------------------
0:00 Introduction
1:24 TCR receptor
2:05 CD4 and CD8
3:23 CD28 and CTLA-4
4:12 VDJ recombination
5:14 T cell development
7:36 Positive and Negative Selection