AIRR-C Seminar Series, April 27, 2023 - Hashem Koohy, Oxford University, UK
535 بار بازدید -
پارسال
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Modelling dynamics of CD8 T
Modelling dynamics of CD8 T cell response to SARS-CoV-2’s emerging variants of concern
Established Speaker: Hashem Koohy, Oxford University, UK
Talk Abstract:
T cells play a crucial role in our immunity by recognizing and eliminating infected and abnormal cells. T cell response is triggered upon T cell recognition of specific antigens presented by MHC molecules on the surface of target cells. However, the underlying rules of the interactions are incompletely understood. Over the past few years, we have been investigating T cell cross-reactivity and common specificity as two key drivers of T cell antigen specificity. In this seminar, I will focus on T cell cross-reactivity, and will introduce a new deep neural network model that we have developed for accurate and reliable prediction of CD8 T cell targets. I will illustrate how we have been using this model to model the dynamics of CD8 T cell response to emerging SARS-CoV-2 mutant variants.
Speaker Bio
Hashem Koohy is an Associate Professor of Systems Immunology at the MRC Weatherall Institute of Molecular Medicine (MRC WIMM), Oxford University. He leads a research group that aims to understand the basic principles of adaptive immunity using integrative machine learning approaches applied to emerging single-cell sequencing data. His group is specifically interested in decoding the antigen-specific T cell response in time and space.
Hashem was awarded his PhD in Systems Biology from the University of Warwick. He then completed two postdoctoral fellowships at the Sanger and Babraham Institute in Cambridge. In 2017, he moved to Oxford to establish his research group, where he currently leads a research programme.
AIRR-C Seminar Series website: https://www.antibodysociety.org/the-a...
Established Speaker: Hashem Koohy, Oxford University, UK
Talk Abstract:
T cells play a crucial role in our immunity by recognizing and eliminating infected and abnormal cells. T cell response is triggered upon T cell recognition of specific antigens presented by MHC molecules on the surface of target cells. However, the underlying rules of the interactions are incompletely understood. Over the past few years, we have been investigating T cell cross-reactivity and common specificity as two key drivers of T cell antigen specificity. In this seminar, I will focus on T cell cross-reactivity, and will introduce a new deep neural network model that we have developed for accurate and reliable prediction of CD8 T cell targets. I will illustrate how we have been using this model to model the dynamics of CD8 T cell response to emerging SARS-CoV-2 mutant variants.
Speaker Bio
Hashem Koohy is an Associate Professor of Systems Immunology at the MRC Weatherall Institute of Molecular Medicine (MRC WIMM), Oxford University. He leads a research group that aims to understand the basic principles of adaptive immunity using integrative machine learning approaches applied to emerging single-cell sequencing data. His group is specifically interested in decoding the antigen-specific T cell response in time and space.
Hashem was awarded his PhD in Systems Biology from the University of Warwick. He then completed two postdoctoral fellowships at the Sanger and Babraham Institute in Cambridge. In 2017, he moved to Oxford to establish his research group, where he currently leads a research programme.
AIRR-C Seminar Series website: https://www.antibodysociety.org/the-a...
پارسال
در تاریخ 1402/02/08 منتشر شده
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535
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