Unlocking Orphan GPCRs with an Innovative Forward Trafficking Approach

The webinar addresses the challenge that much of the GPCR druggable space remains untapped for potential therapeutic targets. To address this gap, a novel systematic, cell-based assay approach to ID chemical probes of orphan GPCRs called the Ligand-Induced Forward Trafficking (LIFT) assay is presented.
This webinar discusses:
Orphan GPCRs as drug targets and the challenges related to lead identification; the development and application of a forward trafficking approach to orphan GPCR lead discovery; a case study targeting GPR20 using the LIFT platform.