Mast Cell Activation Syndrome Versus Histamine Intolerance
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9 ماه پیش
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Are you having a lot
Are you having a lot of histamine issues and histamine symptoms and wondering about Mast Cell Activation Syndrome Versus Histamine Intolerance? Maybe you have itchy, dry skin, post-nasal drip, an ongoing cough, or acid reflux. Lots of histamine symptoms can mimic other conditions. So in this video, we're going to look at the difference between mast cell activation syndrome (MCAS) versus histamine intolerance.
*DAO Supplement: https://geni.us/zb8Ksv (affiliate link)
We'll look at the similarities and differences, as well as some of the things you can do about histamine intolerance and high histamine levels in general.
We look at mast cell activation syndrome (MCAS) versus histamine intolerance. MCAS is not the same as histamine intolerance, but they are often confused or used together. Both conditions involve a problem with too much histamine, and because of this, they can present with similar symptoms. For this reason, the terms are often used interchangeably.
MCAS is a complex and often under-diagnosed condition characterized by abnormal release of mast cell mediators, including histamine. It leads to a wide range of ongoing and varying severity symptoms, which can affect different parts of the body, ranging from digestive to lungs to skin.
With MCAS, mast cells are overactive and hypersensitive to various triggers. Once triggered, they release inflammatory and immune mediators. In people with MCAS compared to normal people, they have many more triggers, and when they do have a trigger, the response is more intense than would typically be expected.
On the other hand, histamine intolerance is a condition characterized by an inability or poor ability to metabolize or break down histamine. This can lead to an accumulation or excess of histamine in the body. There are a few different ways that histamine is broken down in the body. The enzyme in the digestive tract most commonly associated with histamine intolerance is called diamine oxidase (DAO).
When you don't make enough DAO, it is typically due to a genetic or inborn issue. The main job of DAO is to break down the histamine that is already contained within food. DAO can be taken as a supplement when you have the genetics for low DAO production. Sometimes people take it empirically because they think they might have this genetic alteration. The other major enzyme that breaks down histamine in our bodies is histamine N-methyltransferase (HNMT). This enzyme requires a methylation in S-adenosyl methionine (SAMe) specifically in order for it to work properly.
Like DAO, HNMT is under genetic control, and some people don't have well-functioning HNMT enzymes. Additionally, there are methylation SNPs and problems that can lead to not enough SAMe, which is the main cofactor for HNMT. So there are many reasons, and these are just a few of the more common reasons, why someone might have histamine intolerance, meaning an inability or poor ability to break down histamine once it is released or once it is in the body from foods.
In simple cases of too much histamine or poor breakdown, adding some support to these enzymes or decreasing the amount of histamine coming into the body can be very helpful. However, the simple cases usually resolve on their own anyways, and you don't really end up having a lot of issues ongoing.
So it's important if you do have symptoms of high histamine to differentiate between mast cell activation syndrome (MCAS), histamine intolerance, and local mast cell activation that is not part of a syndrome.It's also important to note that sometimes taking support for histamine breakdown and elimination can actually make things worse before it gets better, so if you're super sensitive, you should be very cautious about what you take and how you take it.
However, looking at the overall histamine levels in the foods you're eating and reducing that is generally going to be a safe bet for anyone that's struggling with high histamine symptoms.
*DAO Supplement: https://geni.us/zb8Ksv (affiliate link)
We'll look at the similarities and differences, as well as some of the things you can do about histamine intolerance and high histamine levels in general.
We look at mast cell activation syndrome (MCAS) versus histamine intolerance. MCAS is not the same as histamine intolerance, but they are often confused or used together. Both conditions involve a problem with too much histamine, and because of this, they can present with similar symptoms. For this reason, the terms are often used interchangeably.
MCAS is a complex and often under-diagnosed condition characterized by abnormal release of mast cell mediators, including histamine. It leads to a wide range of ongoing and varying severity symptoms, which can affect different parts of the body, ranging from digestive to lungs to skin.
With MCAS, mast cells are overactive and hypersensitive to various triggers. Once triggered, they release inflammatory and immune mediators. In people with MCAS compared to normal people, they have many more triggers, and when they do have a trigger, the response is more intense than would typically be expected.
On the other hand, histamine intolerance is a condition characterized by an inability or poor ability to metabolize or break down histamine. This can lead to an accumulation or excess of histamine in the body. There are a few different ways that histamine is broken down in the body. The enzyme in the digestive tract most commonly associated with histamine intolerance is called diamine oxidase (DAO).
When you don't make enough DAO, it is typically due to a genetic or inborn issue. The main job of DAO is to break down the histamine that is already contained within food. DAO can be taken as a supplement when you have the genetics for low DAO production. Sometimes people take it empirically because they think they might have this genetic alteration. The other major enzyme that breaks down histamine in our bodies is histamine N-methyltransferase (HNMT). This enzyme requires a methylation in S-adenosyl methionine (SAMe) specifically in order for it to work properly.
Like DAO, HNMT is under genetic control, and some people don't have well-functioning HNMT enzymes. Additionally, there are methylation SNPs and problems that can lead to not enough SAMe, which is the main cofactor for HNMT. So there are many reasons, and these are just a few of the more common reasons, why someone might have histamine intolerance, meaning an inability or poor ability to break down histamine once it is released or once it is in the body from foods.
In simple cases of too much histamine or poor breakdown, adding some support to these enzymes or decreasing the amount of histamine coming into the body can be very helpful. However, the simple cases usually resolve on their own anyways, and you don't really end up having a lot of issues ongoing.
So it's important if you do have symptoms of high histamine to differentiate between mast cell activation syndrome (MCAS), histamine intolerance, and local mast cell activation that is not part of a syndrome.It's also important to note that sometimes taking support for histamine breakdown and elimination can actually make things worse before it gets better, so if you're super sensitive, you should be very cautious about what you take and how you take it.
However, looking at the overall histamine levels in the foods you're eating and reducing that is generally going to be a safe bet for anyone that's struggling with high histamine symptoms.
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