Carcinogenesis|Hallmarks of Cancer#pathology#carcinogenesis #mbbslectures #general_pathology#robbins
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In this video have discussed
In this video have discussed 8 hallmarks of cancer and also about the role of oncogenes and oncoproteins in cancer
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Carcinogenesis|Hallmarks of Cancer#pathology#carcinogenesis #mbbslectures #general_pathology#robbins
Carcinogenesis can be due to chemicals, radiation or microbial agents. It is a multistep process consisting of different steps leading ultimately to malignant tumors. In chemical carcinogenesis there are 2 steps: Initiation and Promotion.
Hallmarks of cancer
8 fundamental changes Protooncogenes, oncogenes & Oncoproteins Role of Oncogenes in cancer
Definition
A disorder of cell growth
Triggered by a series of acquired mutations
Affecting a single cell and its clonal progeny HALLMARKS OF CANCER
1. Self sufficiency in the growth Signals
2. Insensitivity to antigrowth/ growth inhibitory signals
3.Evasion of Apoptosis
4. Limitless Replicative Potential 5. Sustained Angiogenesis
6. The Ability to invade and Metastasize 7. Reprogramming Energy Metabolism
8. Evasion of Immune System
enablers
9. Genomic Instability 10. Tumor promoting inflammation
SELF SUFFICIENCY IN GROWTH SIGNALS
Oncogenes: They promote unregulated proliferation/Autonomous cell growth
(Self sufficiency in growth signals)
The unmutated counterparts of Oncogenes are "proto oncogenes"
Growth factors: Cancer cells develop growth self sufficiency (Synthesize self responsive growth factors) Eg: a. PDGF Glioblastomas
b. TGF-a Sarcomas
c. FGF Breast ca 2. Growth factor receptors:Cancer cells encode for growth
factro receptors. a. EGF-receptor family: ERB-B1 (overexpression)
Squamous cell carcinoma
b. CSF-1 receptor: FMS (point mutation) - Leukemia c. PGDF receptor: PGDF-R (overexpression) - Gliomas 3. Signal transduction proteins - Receive growth
promoting signals.
Eg. RAS family (point mutation) - Ca colon, lung.
Pancreas
4. Nuclear regulatory proteins: Transcriptional activators Eg: C-MYC (translocated) - Burkitt lymphoma N-MYC (Amplification) - Ca lung,
5. Cell cycle regulatory proteins: Eg: Cyclin D (Translocation) Ca breast, Ca esophagus CDK4 (Amplification) Melanoma
Genetic Lesions in Cancer,part 1,Diver and Passenger Mutations,Robbins Pathology chapter 6,Neoplasia
Cancer genes,proto oncogenes, Tumour suppressor gene, Apoptotic and Anti Apoptotic genes #pathology
Characteristics of Benign and Malignant Neoplasms,Part-2,Local invasion, Metastasis#pathology#neoplasia
Local invasion;
This spread is a cellular process, in which cancer cells become mobilized and invade out and away from the primary tumor site. Local invasion causes debilitating tissue and organ destruction in glioma and lung and head, neck, and salivary gland tumors
Metastasis;
In metastasis, cancer cells break away from the original (primary) tumor, travel through the blood or lymph system, and form a new tumor in other organs or tissues of the body. The new, metastatic tumor is the same type of cancer as the primary tumor.
Characteristics of Benign and Malignant tumors||Differentiation and anaplasia||Dymoplasia #neoplasia
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anaplasia,differentiation,differentiation and anaplasia /of neoplasia(1),diffreniciation and anaplasia,differentiation vs anaplasia,anaplasia definition,anaplasia meaning,#anaplasia,what is anaplasia,cellular adaptation of growth and differentiation,anaplastic,differenciation,what does anaplasia stand for,metaplasia and dysplasia,anaplasia explanation,lack of differentiation,anaplasia pronunciation,anaplasia dictionary,cell differentiation
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Nomenclature of Neoplasia, Components of Neoplasia,Mixed Tumor,Teratoma#pathology#neoplasia#robbins
Neoplasia|Robbins Pathology chapter 6|Introduction to Neoplasia robbins_pathology#pathology#cancer
neoplasia,neoplasia definition,neoplasia maligna,malignant neoplasia,
Brainless Medico
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please like share and subscribe.
must share with fellows.
Carcinogenesis|Hallmarks of Cancer#pathology#carcinogenesis #mbbslectures #general_pathology#robbins
Carcinogenesis can be due to chemicals, radiation or microbial agents. It is a multistep process consisting of different steps leading ultimately to malignant tumors. In chemical carcinogenesis there are 2 steps: Initiation and Promotion.
Hallmarks of cancer
8 fundamental changes Protooncogenes, oncogenes & Oncoproteins Role of Oncogenes in cancer
Definition
A disorder of cell growth
Triggered by a series of acquired mutations
Affecting a single cell and its clonal progeny HALLMARKS OF CANCER
1. Self sufficiency in the growth Signals
2. Insensitivity to antigrowth/ growth inhibitory signals
3.Evasion of Apoptosis
4. Limitless Replicative Potential 5. Sustained Angiogenesis
6. The Ability to invade and Metastasize 7. Reprogramming Energy Metabolism
8. Evasion of Immune System
enablers
9. Genomic Instability 10. Tumor promoting inflammation
SELF SUFFICIENCY IN GROWTH SIGNALS
Oncogenes: They promote unregulated proliferation/Autonomous cell growth
(Self sufficiency in growth signals)
The unmutated counterparts of Oncogenes are "proto oncogenes"
Growth factors: Cancer cells develop growth self sufficiency (Synthesize self responsive growth factors) Eg: a. PDGF Glioblastomas
b. TGF-a Sarcomas
c. FGF Breast ca 2. Growth factor receptors:Cancer cells encode for growth
factro receptors. a. EGF-receptor family: ERB-B1 (overexpression)
Squamous cell carcinoma
b. CSF-1 receptor: FMS (point mutation) - Leukemia c. PGDF receptor: PGDF-R (overexpression) - Gliomas 3. Signal transduction proteins - Receive growth
promoting signals.
Eg. RAS family (point mutation) - Ca colon, lung.
Pancreas
4. Nuclear regulatory proteins: Transcriptional activators Eg: C-MYC (translocated) - Burkitt lymphoma N-MYC (Amplification) - Ca lung,
5. Cell cycle regulatory proteins: Eg: Cyclin D (Translocation) Ca breast, Ca esophagus CDK4 (Amplification) Melanoma
Genetic Lesions in Cancer,part 1,Diver and Passenger Mutations,Robbins Pathology chapter 6,Neoplasia
Cancer genes,proto oncogenes, Tumour suppressor gene, Apoptotic and Anti Apoptotic genes #pathology
Characteristics of Benign and Malignant Neoplasms,Part-2,Local invasion, Metastasis#pathology#neoplasia
Local invasion;
This spread is a cellular process, in which cancer cells become mobilized and invade out and away from the primary tumor site. Local invasion causes debilitating tissue and organ destruction in glioma and lung and head, neck, and salivary gland tumors
Metastasis;
In metastasis, cancer cells break away from the original (primary) tumor, travel through the blood or lymph system, and form a new tumor in other organs or tissues of the body. The new, metastatic tumor is the same type of cancer as the primary tumor.
Characteristics of Benign and Malignant tumors||Differentiation and anaplasia||Dymoplasia #neoplasia
Like video,Share and subscribe so that more people can get benefits,
anaplasia,differentiation,differentiation and anaplasia /of neoplasia(1),diffreniciation and anaplasia,differentiation vs anaplasia,anaplasia definition,anaplasia meaning,#anaplasia,what is anaplasia,cellular adaptation of growth and differentiation,anaplastic,differenciation,what does anaplasia stand for,metaplasia and dysplasia,anaplasia explanation,lack of differentiation,anaplasia pronunciation,anaplasia dictionary,cell differentiation
benign tumor,characteristics of benign and malignant tumors anaplasia,malignant tumor,malignant,properties of benign and malignant tumor,benign and malignant tumors,malignant tumours,characteristics of benign & malignant neoplasms,benign,charecters of benign tumor & malignant tumor,benign and malignant tumors pathology,benign tumor and malignant tumor,benign tumours,difference between benign and malignant tumor,differences between benign and malignant tumor
Like video,Share and subscribe so that more people can get benefits,
Nomenclature of Neoplasia, Components of Neoplasia,Mixed Tumor,Teratoma#pathology#neoplasia#robbins
Neoplasia|Robbins Pathology chapter 6|Introduction to Neoplasia robbins_pathology#pathology#cancer
neoplasia,neoplasia definition,neoplasia maligna,malignant neoplasia,
Brainless Medico
Bell Icon For More Videos
medical study tips,
medical study in hindi,
medical study in canada,
medical study in germany, medical study in usa,
medical study point,
medical study with me,
medical study vlog,
medical study abroad,
how to study medical books, medical study center,
medical for canada study visa, medical college study,
medical coding study guide,
medical study diary
neoplasia pathology robbins,
neoplasia pathology,
neoplasia pathology in hindi,
neoplasia,neoplasia i love pathology,
neoplasia pathology lecture,
neoplasia pathology selfless medicose,
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