Keto & Cholesterol: Lipid Energy Model and the Oreo Experiment | Nick Norwitz | The Proof

Oreo cookies or statins – which is more effective in reducing LDL cholesterol? The results from one study might surprise you. Join me in Episode #323 as I sit down with Oxford PhD graduate and Harvard Medical student Dr Nick Norwitz to discuss the lipid energy model, what it has to do with Oreos, and how different diets affect your health. 👇 Visit The Proof website for the full show notes and supporting studies. 👇 theproof.com/podcast/ Nick Norwitz, PhD is a 28-year-old 4th year medical student at Harvard Medical School. Prior to pursuing a career in medicine, he attended Dartmouth College where he majored in Cell Biology and Biochemistry and graduated Valedictorian. He then went on to complete a PhD at the University of Oxford in Neuro-Metabolism before returning to Boston to complete his MD at Harvard. Personally, Nick practices a ketogenic diet, which he uses therapeutically to treat inflammatory bowel disease. Connect with Nick Norwitz, PhD: - Twitter/X: x.com/nicknorwitz - Instagram: www.instagram.com/nicknorwitz/ - YouTube:    / @nicknorwitzphd   Specifically, we cover: Introduction (00:00) The Importance of Curiosity in Scientific Progress (02:19) Exploring the Oreo vs. Statin Experiment on Lean Mass Hyper Responders (06:32) Scientific and Clinical Impact of the Oreo Study (22:43) Addressing Criticisms and Misinterpretations of the Study (32:27) Navigating Statin Discussions on Social Media (38:07) Debunking Claims About PCSK9 Inhibitors (50:58) Challenging Misinformation in Health Communities (56:55) The Lipid Energy Model and Lean Mass Hyper Responders Explained (01:05:39) Defining Lean Mass Hyper Responders: Key Terminology (01:12:59) Practical Advice for Lean Mass Hyper Responders (01:29:15) The Carnivore Kid: An Intriguing Case Study (01:40:28) Personal Struggles with Ulcerative Colitis and Starting Keto (01:44:04) Balancing Medication and Personal Health Choices (01:49:11) Debating Dietary Interventions for Inflammatory Bowel Disease (02:09:49) Challenges in Dietary Research and Medical Interventions (02:24:35) Introducing the Lipid Energy Model and Its Mechanisms (02:33:29) Debating the Validity of the Lipid Energy Model (02:43:09) Long-Term Effects of Ketosis and Carb Restriction (02:51:11) Critiques and Limitations of the Lipid Energy Model (02:55:57) ApoB-Containing Lipoproteins and Atherosclerosis (03:02:30) Current Research and Future Directions on LMHR (03:05:21) Exploring Inflammatory Responses to Fibre (03:14:52) The Link Between Saturated Fats and Heart Disease (03:19:29) Closing Thoughts on Effective Scientific Communication (03:24:09) The Lean Mass Hyper Responders Debate: Addressing Frustrations (03:31:12) Understanding Carbohydrate Reintroduction Physiology (03:45:38) Diet-Specific Strategies to Lower ApoB (03:53:56) Examining Claims About ApoB and Cardiovascular Disease (04:00:30) Trade-offs in Lowering ApoB Levels (04:11:34) Exploring the Link Between All-Cause Mortality and ApoB (04:21:22) Lean Mass Hyper Responders and ApoB: A Unique Profile (04:43:34) Concluding Thoughts and Future Discussion Topics (04:46:50) This episode is brought to you by: 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Head to 38tera.com/ and use code THEPROOF for a discount at checkout. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to eimele.com/ and use code SIMON at checkout for 10% off your first order. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Simon Hill, MSc, BSc (Hons) Creator of theproof.com/ and host of The Proof with Simon Hill theproof.com/podcast/ Author of The Proof is in the Plants theproof.com/book/ Watch the episodes on YouTube youtube.com/c/TheProofWithSimonHill/videos or listen on Apple podcasts.apple.com/au/podcast/the-proof-with-simon… / Spotify open.spotify.com/show/7bAIJCVgnquxXZuQCdZyTi?si=84… Connect with me on Instagram www.instagram.com/theproof/, Twitter mobile.twitter.com/theproof, and Facebook facebook.com/theproofwithsimonhill Nourish your gut with my Plant-Based Ferments Guide theproof.com/ferments/ Download my complimentary Two-Week Meal Plan plantproof.com/mealplan and high protein Plant Performance recipe book theproof.com/performance/

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