Driving on Interstate 10 from Fort Stockton, TX to El Paso

I-10 enters Texas northwest of El Paso near Anthony and travels southward, concurrent with US 85 and US 180. US 85 splits off in West El Paso at exit 13 (Sunland Park Drive, Paisano Drive), where US 85 heads south on Paisano Drive, through downtown El Paso, and ends at the Stanton Street Bridge and the border with Mexico via local streets. As of Summer 2016, Interstate 10 through El Paso is undergoing a major construction project, which seeks to link North/South Desert Boulevard (the westside frontage roads) with Gateway East and Gateway West (the central and eastside frontage roads). Several miles of frontage road are being built where none previously existed. I-10/US 180 continues turning to the east towards downtown El Paso. I-10 then meets I-110 and US 54 (the "Patriot Freeway", or North–South Freeway) in a complex, three-level interchange referred to by locals as the "Spaghetti Bowl." I-10 and US 180 diverge east of downtown at exit 23B (Paisano Drive) as US 180 heads off to the northeast (joining US 62 and Paisano Drive northbound) and I-10 to the southeast. I-10's frontage road system is called Desert Boulevard in West El Paso, and Gateway Boulevard in Central and East El Paso. Of these, Gateway East Boulevard is the longest, extending continuously for roughly 22 miles (35 km). Heading towards Tornillo and Fabens, I-10 turns to the southeast and begins to parallel the Rio Grande and Mexican border for approximately 60 miles

I-10 leaves the Rio Grande with a primarily eastward heading. Just east of Kent, the western terminus of I-20 intersects with I-10. I-20 heads northeast towards the Dallas-Fort Worth area and I-10 continues to head east. US 67 runs concurrently with I-10 for a stretch and the La Entrada al Pacifico trade corridor is a part of this stretch of I-10. Near Junction, I-10 begins a more southeastwardly course as it heads toward the San Antonio metropolitan area. Near Comfort, I-10 and US 87 begin a concurrency that carries on into San Antonio.

Due to I-10 crossing some of the most rural and sparsely inhabited parts of the United States, notably the Trans-Pecos Region it has several unique features that differentiate it from other Interstate Highways. I-10 is one of the very few Interstates that has at-grade intersections (roads that intersect it at a 90-degree angle, as opposed to an overpass or underpass with on and off ramps). These are private access roads (mostly from large ranches) which occur over a limited stretch in western Texas.