Optimizing G Protein-Coupled Receptor Expression in Mammalian Cells

Presented At:
Gibco ExpressionWorld 2018

Presented By:
Dean Staus, PhD - Postdoctoral Researcher, Duke University
BIOGRAPHY:
Dean Staus received his Bachelor of Science degree in biology from the University of Wisconsin, Whitewater and his PhD in pathology from the University of North Carolina, Chapel Hill. He is currently a postdoctoral researcher in Dr. Robert Lefkowitz's laboratory at Duke University.

Laura Wingler, PhD - Postdoctoral Researcher, Duke University
BIOGRAPHY:
Laura Wingler received her Bachelor of Science degrees in chemistry and biochemistry from North Carolina State University and her PhD in chemistry from Columbia University. She is currently a postdoctoral researcher in Dr. Robert Lefkowitz's laboratory at Duke University.

Webinar:
Optimizing G Protein-Coupled Receptor Expression in Mammalian Cells

Webinar Abstract:
G protein-coupled receptors (GPCRs) regulate virtually all known physiological processes and are a premier class of drug targets.  However, a detailed mechanistic understanding of their complex activation mechanisms has been hindered by the difficulty of expressing and purifying these membrane proteins.  We will describe how mammalian expression provides a versatile platform for high-level GPCR expression.  In addition, we will discuss how new expression technologies can address the challenges that have previously limited the scope of mammalian expression systems for biochemical and biophysical studies of GPCRs.

Sponsored By:
Thermo Fisher Scientific

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