Dabigatran (Pradaxa) Mechanism of action 【USMLE, Biochemistry】
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Dabigatran (Pradaxa) reversibly binds to
Dabigatran (Pradaxa) reversibly binds to the active site on the thrombin molecule, and prevents thrombin-mediated activation of coagulation factors. This video shows the detailed mechanism of action of dabigatran. You'll check your knowledge on it as well.
#pharmacologymadeeasy #biochemistrynotes #pharmacologylecturesforpharmacystudents
(Reference) I express my gratitude and respect for your wonderful achievements.
1. PRADAXA® (dabigatran etexilate mesylate) capsules for oral use Initial U.S. Approval: 2010- FDA
https://www.accessdata.fda.gov/drugsa...
2. Miguel Angel Martin-Piedra.
Dabigatran and rivarixaban, new oral anticoagulants. New approaches in Dentistry
Journal of Clinical and Experimental Dentistry 2(1) Feb. 2010
DOI: 10.4317/jced.2.e1
3. Dabigatran (Pradaxa)
J. Comin and D.F. Kallmes
American Journal of Neuroradiology March 2012, 33 (3) 426-428;
DOI: https://doi.org/10.3174/ajnr.A3000.
4. Ming-HuiDong, Hai-FengChen, Yu-JieRen, Fang-MingShao.
Molecular modeling studies, synthesis and biological evaluation of dabigatran analogues as thrombin inhibitors. Bioorg Med Chem. 2016 Jan 15;24(2):73-84.
https://doi.org/10.1016/j.bmc.2015.11...
5. Carolyn M. Millar and David A. Lane
Blocking direct inhibitor bleeding
Blood 2013 121:3543-3544; doi: https://doi.org/10.1182/blood-2013-03...
6. Pete Lollar, MD
The Way Things Work: Thrombin
Diffusion. July-August 2011, Volume 8, Issue 4
7. Sigma Aldrich
Fibrinogen/Fibrin
sigmaaldrich.com
8. Priscilla Elizondo and Aaron L. Fogelson
A Mathematical Model of Venous Thrombosis Initiation. Biophys J. 2016 Dec 20; 111(12): 2722–2734.
doi: 10.1016/j.bpj.2016.10.030
9. Factor XIII crosslinks fibrin
File:Stabilisation de la fibrine par le factor XIII.png
(Opening Movie)
light house; Pixabay pixabay.com
music; Seashore Synthetic. OtoLogic. https://otologic.jp
(Music) Youtube free music
#pharmacologymadeeasy #biochemistrynotes #pharmacologylecturesforpharmacystudents
(Reference) I express my gratitude and respect for your wonderful achievements.
1. PRADAXA® (dabigatran etexilate mesylate) capsules for oral use Initial U.S. Approval: 2010- FDA
https://www.accessdata.fda.gov/drugsa...
2. Miguel Angel Martin-Piedra.
Dabigatran and rivarixaban, new oral anticoagulants. New approaches in Dentistry
Journal of Clinical and Experimental Dentistry 2(1) Feb. 2010
DOI: 10.4317/jced.2.e1
3. Dabigatran (Pradaxa)
J. Comin and D.F. Kallmes
American Journal of Neuroradiology March 2012, 33 (3) 426-428;
DOI: https://doi.org/10.3174/ajnr.A3000.
4. Ming-HuiDong, Hai-FengChen, Yu-JieRen, Fang-MingShao.
Molecular modeling studies, synthesis and biological evaluation of dabigatran analogues as thrombin inhibitors. Bioorg Med Chem. 2016 Jan 15;24(2):73-84.
https://doi.org/10.1016/j.bmc.2015.11...
5. Carolyn M. Millar and David A. Lane
Blocking direct inhibitor bleeding
Blood 2013 121:3543-3544; doi: https://doi.org/10.1182/blood-2013-03...
6. Pete Lollar, MD
The Way Things Work: Thrombin
Diffusion. July-August 2011, Volume 8, Issue 4
7. Sigma Aldrich
Fibrinogen/Fibrin
sigmaaldrich.com
8. Priscilla Elizondo and Aaron L. Fogelson
A Mathematical Model of Venous Thrombosis Initiation. Biophys J. 2016 Dec 20; 111(12): 2722–2734.
doi: 10.1016/j.bpj.2016.10.030
9. Factor XIII crosslinks fibrin
File:Stabilisation de la fibrine par le factor XIII.png
(Opening Movie)
light house; Pixabay pixabay.com
music; Seashore Synthetic. OtoLogic. https://otologic.jp
(Music) Youtube free music
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