Diphenoxylate/Atropine Nursing Considerations, Side Effects, and Mechanism of Action

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Diphenoxylate/Atropine

Generic Name: diphenoxylate/atropine

Trade Name: Lomotil

Indication: Treatment for diarrhea Action Inhibits GI motility via anticholinergic effects

Therapeutic Class: antidiarrheal

Pharmacologic Class: anticholinergic

Nursing Considerations:
 contraindicated with angle-closure glaucoma, dehydration
 structurally related to opioids so use caution with patients that have allergies to opioids
 may cause constipation, tachycardia, dizziness, ileus
 monitor liver function as medication is excreted by the liver
 insure that client is taking medication as prescribed and not double dosing

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