Warburg effect. Energy Production In Cancer Cell. How Does it Benefit Cancer Cells?

Foxterrier
Foxterrier
6.1 هزار بار بازدید - 3 سال پیش - 0:01
0:01 What is it Warburg Effect
MECHANISM EXPLAINED
1:14 Normal Glycolysis
6:37 Glycolysis in Cancer cell
6:58 Why Lactate cause acidosis
3:33 Metabolic properties of Warburg effect.
WHY?
8:28 Enegy benefit
11:03 Acid-mediated invasion hypothesis  

Why patients with cancer lose weight.

#usmle  #step1  #step2  #medicine  #pathology  #physiology  #education  #medicalschool  #pharmacology  #biochemistry  #highyield  #lab

Liberti MV, Locasale JW. The Warburg Effect: How Does it Benefit Cancer Cells? [published correction appears in Trends Biochem Sci. 2016 Mar;41(3):287] [published correction appears in Trends Biochem Sci. 2016 Mar;41(3):287]. Trends Biochem Sci. 2016;41(3):211-218. doi:10.1016/j.tibs.2015.12.001 Link - https://www.ncbi.nlm.nih.gov/pmc/arti...

DeBerardinis, R. J., & Chandel, N. S. (2020). We need to talk about the Warburg effect. Nature metabolism, 2(2), 127–129. https://doi.org/10.1038/s42255-020-01...

This video is a review of the Warburg effect in cancer cells. Warburg effect definition.   Explained the mechanism of the Warburg effect for step 1 and step 2 pathology.  How Warburg effect cause atp robbery. The Warburg hypothesis how neoplastic cells deprive normal cells of glucose. Why cancer cause weight loss and cachexia. How TCA cycle affects Warbug metabolism. The reason why cancer cells with sufficient amount of oxygen use anaerobic glycolysis and produce Lactate instead of aerobic glycolysis. The role of LDH ( Lactate dehydrogenase) in cancer cells and Warburg metabolism. How lactate cause polimerization of tissue-associated macrophages and promote cancer growth. Reverse warburg effect. Biochemical and biological approach to cancer metabolism.

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