9. Isoenzymes or Isozymes

Definition
different forms of the same enzyme catalyzing same reaction

How they are formed
1. Different genes- true isozymes
2. all variants are present in same individual
3. isoforms- due to post translational modification
4. allozymes- from different alleles

characteristics
1. electrophoretic mobility
2. substrate specificity and Km
3. Heat stability
4. Inhibitor
5. Coenzymes
6. Antibody sensitivity
7. Tissue of origin

examples
LDH- 1 to 5
CK 1 to 3
ALP-6
clinical significance

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