MDMA synthesis in 3 steps & how it could help PTSD therapy (educational) | Chemistry & Science

Total Synthesis
Total Synthesis
189.1 هزار بار بازدید - 2 سال پیش - 🧠 Did you know that
🧠 Did you know that MDMA-assisted therapy was recently suggested to be highly effective for people with severe PTSD? In this video, we will break down MDMA's history and discovery, synthetic approaches from the literature - including a kilo-scale process route - and clinical data from a Phase 3 study investigating MDMA's therapeutic benefit. https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters!!! https://www.instagram.com/totalsynthesis_official/ 👉 Follow me on Instagram to follow updates on other random chemistry research and interesting news! https://total-synthesis.com/ https://total-synthesis.com/mdma-synthesis/ https://www.total-synthesis.com/ * Note, some slides spell safrole as saffrole Please drop a like and comment to support the video's visibility, activate notifications and subscribe to the channel so you do not miss future videos https://www.seevid.ir/fa/w/onaKmEUtNbc MDMA might have valuable therapeutic potential https://www.seevid.ir/fa/w/onaKmEUtNbc Uncontrolled drug use is dangerous!!! https://www.seevid.ir/fa/w/onaKmEUtNbc History and discovery of MDMA https://www.seevid.ir/fa/w/onaKmEUtNbc Organic synthesis and chemical reactions: Safrole, piperonal, GMP synthesis https://www.seevid.ir/fa/w/onaKmEUtNbc PTSD burden of disease and unmet need https://www.seevid.ir/fa/w/onaKmEUtNbc Clinical trial design and results https://www.seevid.ir/fa/w/onaKmEUtNbc Short-term MDMA safety seems acceptable - still, long-term or regular use is discouraged! https://www.seevid.ir/fa/w/onaKmEUtNbc Outlook on potential FDA approval Disclaimer - This channel does not provide medical advice! No information on this channel is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of information on Youtube. Key references: - Fully Validated, Multi-Kilogram cGMP Synthesis of MDMA (ACS Omega 2022, 7, 900−907) - MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study (Nature Medicine 2021, 27, 1025) - The origin of MDMA (‘Ecstasy’) – separating the facts from the myth (Die Pharmazie 2006, 61, 966) Some recommended books on organic synthesis: - Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) - Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of functional group reactions and applications thereof with common conditions) - Nicolaou; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) - Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life) - Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)
2 سال پیش در تاریخ 1402/01/06 منتشر شده است.
189,182 بـار بازدید شده
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