Development of a Cell-Based Reporter Assay for Measuring ADAR1 Editing Activity for Drug Discovery

Adenosine Deaminase Acting on RNA (ADAR) enzymes perform adenosine to inosine base editing in RNA, particularly targeting adenosines located within a specific double-stranded stem-loop motif.  ADAR1 plays important roles in inflammation, autoimmune diseases, and cancer, and represents an attractive target for therapeutic development. BPS Bioscience has developed and validated high-throughput, cell-based assays for measuring ADAR1 editing activity.  This webinar will describe the principle of these cell-based assays, present data, and discuss the scientific applications of the cell lines.

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• #rna_editing
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• #luciferase_reporter_cell_lines