Ab-Initio Protein Structure Prediction (part 1)

Lecture from course 540.414/614: Protein Structure Prediction and Design

Ab-Initio Protein Structure Prediction (part 1)

* Underlying Concepts
** Sequence to Structure (00:10)
** Levinthal and Anfinson (5:20)
** Searching and Scoring (10:00)
** Ensembles vs Optimization (14:46)
* Search
** Monte Carlo Folding Algorithm (18:35)
*** Multi-Start (30:03)
*** Simulated Annealing (33:05)
*** Fragments (36:35)
* Scoring
** Knowledge-Based Score Function Development (48:45)
*** Centroid Representation (49:34)
*** Bayes' Theorem (56:50)
*** Sequence-Independent Terms (1:03:50)

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