The MOST UNDER-RATED HEROS in Our Body: Anticoagulant Factors
7 هزار بار بازدید -
5 سال پیش
-
Explore our entire animation video
Explore our entire animation video library at: https://www.nonstopneuron.com/
All videos from physiology of blood: https://www.nonstopneuron.com/post/ph...
Video Summary:
Preventing unnecessary clot formation at normal healthy vasculature is function of endothelial cell lining of the blood vessel, endogenous antiplatelet factors and endogenous anticoagulant factors. Endothelial cells have negative charge which repels platelets and prevents platelet adhesion. They separate tissue factor (factor III) from factor VII present in blood. Also, they are source of NO and PGI2 and many anticoagulant factors. In antiplatelet squad we have NO and PGI2. They inhibit platelets. Now the anticoagulant factors. Antithrombin III inhibit thrombin, factor Xa and also factor IXa, XIa and XIIa. Heparan sulphate and heparin have no intrinsic anticoagulant activity. However, they potentiate antithrombin III. Thrombomodulin complexes with thrombin and thereby removes it from circulation. Also, it alters the behaviour of thrombin which then activates an anticoagulant, protein C. Protein C inactivates factor Va and VIIIa. Protein S serves as cofactor for protein C. Tissue factor pathway inhibitor first inhibits factor Xa, and then factor VIIa. Fibrin absorbs thrombin and prevents it from spreading into the circulation.
● Hemostasis Physiology:
• Platelet Plug Formation: Platelet Plug Formation is SO AMAZING
• Blood Coagulation Cascade: You Will FALL IN LOVE WITH PHYSIOLOGY...
• Clot Retraction & Fibrinolysis: Clot Retraction & Fibrinolysis
• Anticoagulant Factors: (Current video)
• Vitamin K: Biochemistry/Pharmacology: Vitamin K: Functions, Mechanism of Ac...
● Drugs affecting Hemostasis:
• Heparin, LMWH & Fondaparinux: You Will Know EVERYTHING About Hepari...
• Warfarin (Vitamin K Antagonists): I Will LEAVE YOUTUBE IF This Video Ge...
• Fibrinolytics & Antifibrinolytics: Fibrinolytics & Antifibrinolytics: Ph...
• Antiplatelet Drugs: Antiplatelet Drugs: Aspirin, Clopidog...
● Follow me at:
• Facebook: Facebook: NonstopNeuron
• Instagram: Instagram: NonstopNeuron
DISCLAIMER: This video is for education purpose only. Although every effort is made to ensure accuracy of material, viewer should refer to the appropriate regulatory body/authorised websites, guidelines and other suitable sources of information as deemed relevant and applicable. In view of possibility of human error or changes in medical science, any person or organization involved in preparation of this work accepts no responsibility for any errors or omissions or results obtained from use of information in this video.
All videos from physiology of blood: https://www.nonstopneuron.com/post/ph...
Video Summary:
Preventing unnecessary clot formation at normal healthy vasculature is function of endothelial cell lining of the blood vessel, endogenous antiplatelet factors and endogenous anticoagulant factors. Endothelial cells have negative charge which repels platelets and prevents platelet adhesion. They separate tissue factor (factor III) from factor VII present in blood. Also, they are source of NO and PGI2 and many anticoagulant factors. In antiplatelet squad we have NO and PGI2. They inhibit platelets. Now the anticoagulant factors. Antithrombin III inhibit thrombin, factor Xa and also factor IXa, XIa and XIIa. Heparan sulphate and heparin have no intrinsic anticoagulant activity. However, they potentiate antithrombin III. Thrombomodulin complexes with thrombin and thereby removes it from circulation. Also, it alters the behaviour of thrombin which then activates an anticoagulant, protein C. Protein C inactivates factor Va and VIIIa. Protein S serves as cofactor for protein C. Tissue factor pathway inhibitor first inhibits factor Xa, and then factor VIIa. Fibrin absorbs thrombin and prevents it from spreading into the circulation.
● Hemostasis Physiology:
• Platelet Plug Formation: Platelet Plug Formation is SO AMAZING
• Blood Coagulation Cascade: You Will FALL IN LOVE WITH PHYSIOLOGY...
• Clot Retraction & Fibrinolysis: Clot Retraction & Fibrinolysis
• Anticoagulant Factors: (Current video)
• Vitamin K: Biochemistry/Pharmacology: Vitamin K: Functions, Mechanism of Ac...
● Drugs affecting Hemostasis:
• Heparin, LMWH & Fondaparinux: You Will Know EVERYTHING About Hepari...
• Warfarin (Vitamin K Antagonists): I Will LEAVE YOUTUBE IF This Video Ge...
• Fibrinolytics & Antifibrinolytics: Fibrinolytics & Antifibrinolytics: Ph...
• Antiplatelet Drugs: Antiplatelet Drugs: Aspirin, Clopidog...
● Follow me at:
• Facebook: Facebook: NonstopNeuron
• Instagram: Instagram: NonstopNeuron
DISCLAIMER: This video is for education purpose only. Although every effort is made to ensure accuracy of material, viewer should refer to the appropriate regulatory body/authorised websites, guidelines and other suitable sources of information as deemed relevant and applicable. In view of possibility of human error or changes in medical science, any person or organization involved in preparation of this work accepts no responsibility for any errors or omissions or results obtained from use of information in this video.
5 سال پیش
در تاریخ 1398/09/06 منتشر شده
است.
7,039
بـار بازدید شده