Michael Levin | Cell Intelligence in Physiological and Morphological Spaces
120.6 هزار بار بازدید -
2 سال پیش
-
Talk kindly contributed by Michael
Talk kindly contributed by Michael Levin in SEMF's 2022 Spacious Spatiality
https://semf.org.es/spatiality
TALK ABSTRACT
Life was solving problems in metabolic, genetic, physiological, and anatomical spaces long before brains and nervous systems appeared. In this talk, I will describe remarkable capabilities of cell groups as they create, repair, and remodel complex anatomies. Anatomical homeostasis reveals that groups of cells are collective intelligences; their cognitive medium is the same as that of the human mind: electrical signals propagating in cell networks. I will explain non-neural bioelectricity and the tools we use to track the basal cognition of cells and tissues and control their function for applications in regenerative medicine. I will conclude with a discussion of our framework based on evolutionary scaling of intelligence by pivoting conserved mechanisms that allow agents, whether designed or evolved, to navigate complex problem spaces.
TALK MATERIALS
· The Electrical Blueprints that Orchestrate Life (TED Talk): https://www.ted.com/talks/michael_lev...
· Michael Levin's interviews and presentations: https://ase.tufts.edu/biology/labs/le...
· Michael Levin's publications: https://ase.tufts.edu/biology/labs/le...
· The Institute for Computationally Designed Organisms (ICDO): https://icdorgs.org/
MICHAEL LEVIN
Department of Biology, Tufts University: https://as.tufts.edu/biology
Tufts University profile: https://ase.tufts.edu/biology/labs/le...
Wyss Institute profile: https://wyss.harvard.edu/team/associa...
Wikipedia: https://en.wikipedia.org/wiki/Michael...)
Google Scholar: https://scholar.google.com/citations?...
Twitter: Twitter: drmichaellevin
LinkedIn: LinkedIn: michael-levin-b0983a6
SEMF NETWORKS
Website: https://semf.org.es
Twitter: Twitter: semf_nexus
LinkedIn: LinkedIn: semf-nexus
Instagram: Instagram: semf.nexus
Facebook: Facebook: semf.nexus
MUSIC
baroquenoise
TIMESTAMPS
00:00:00 INTRODUCTION
00:01:27 All intelligence is collective intelligence
00:03:45 Main points of the talk
00:04:32 Single cell spatial competencies
00:06:19 Outline of the talk
00:06:46 PLASTICITY
00:08:18 Planarian memories survive brain regeneration
00:09:29 Tadpoles can see with artificially implanted eyes
00:10:42 Biological systems have competency in different scales and spaces
00:12:56 Planaria regenerates head with new adaptive gene expression
00:15:06 Technological Approach to Mind Everywhere
00:16:34 INTELLIGENT NAVIGATION IN MORPHOSPACE
00:16:34 Where are anatomy and shape encoded in biology?
00:17:55 Biomedical endgame: anatomical compiler
00:19:01 Unpredictability of anatomy of chimeric species: frogolotls
00:19:59 Hardware and software: analogy between nowadays biology and 40s-50s computer science
00:21:15 What is morphospace?
00:23:26 Examples of natural regeneration
00:25:15 Cells change molecular mechanisms to adapt shape to artifical constraints
00:27:05 Induced frog leg regenration takes different path than default limb development
00:28:08 Facial mispatterning in tadpoles still ends in normal frog faces
00:29:36 Feedback loops in pattern homeostasis and goal-directedness
00:31:34 BIOELECTRICITY
00:31:38 Usual example of bioelectricity explaining goal-directedness: the brain
00:32:49 Generalizing: non-brain tissues also encode goals through bioelectricity
00:34:36 Reading and writing electrical information in non-brain tissues
00:35:29 Reading #1: “electric face” before face development
00:36:45 Reading #2: electric signature before tumor development
00:37:12 Writing electrical information in non-brain tissues using neuroscience tools
00:38:12 Writing #1: inducing voltage patterns that develop organs and limbs
00:40:16 Writing #2: inducing limb regeneration
00:42:08 Writing #3: inducing anatomical memory that produces two-headed planaria when injured
00:47:01 Writing #4: inducing shape changes
00:48:36 Developing quantitative, predictive models
00:49:27 Writing #5: correcting brain defects using model predictions
00:51:14 Electroceutical drugs
00:52:09 TECHNOLOGICAL APPROACH TO MIND EVERYWHERE
00:52:18 Different scales of biological systems have different goals
00:55:00 Potential application to reverse cancer
00:55:48 Diversity of intelligences
00:57:16 Multi-scale control and up-scaling goals across spaces
00:59:01 Behavior of skin cells clusters when isolated: xenobots
01:07:15 Overview of the Technological Approach to Mind Everywhere
01:08:00 The space of intelligent agents and its implications for ethics
https://semf.org.es/spatiality
TALK ABSTRACT
Life was solving problems in metabolic, genetic, physiological, and anatomical spaces long before brains and nervous systems appeared. In this talk, I will describe remarkable capabilities of cell groups as they create, repair, and remodel complex anatomies. Anatomical homeostasis reveals that groups of cells are collective intelligences; their cognitive medium is the same as that of the human mind: electrical signals propagating in cell networks. I will explain non-neural bioelectricity and the tools we use to track the basal cognition of cells and tissues and control their function for applications in regenerative medicine. I will conclude with a discussion of our framework based on evolutionary scaling of intelligence by pivoting conserved mechanisms that allow agents, whether designed or evolved, to navigate complex problem spaces.
TALK MATERIALS
· The Electrical Blueprints that Orchestrate Life (TED Talk): https://www.ted.com/talks/michael_lev...
· Michael Levin's interviews and presentations: https://ase.tufts.edu/biology/labs/le...
· Michael Levin's publications: https://ase.tufts.edu/biology/labs/le...
· The Institute for Computationally Designed Organisms (ICDO): https://icdorgs.org/
MICHAEL LEVIN
Department of Biology, Tufts University: https://as.tufts.edu/biology
Tufts University profile: https://ase.tufts.edu/biology/labs/le...
Wyss Institute profile: https://wyss.harvard.edu/team/associa...
Wikipedia: https://en.wikipedia.org/wiki/Michael...)
Google Scholar: https://scholar.google.com/citations?...
Twitter: Twitter: drmichaellevin
LinkedIn: LinkedIn: michael-levin-b0983a6
SEMF NETWORKS
Website: https://semf.org.es
Twitter: Twitter: semf_nexus
LinkedIn: LinkedIn: semf-nexus
Instagram: Instagram: semf.nexus
Facebook: Facebook: semf.nexus
MUSIC
baroquenoise
TIMESTAMPS
00:00:00 INTRODUCTION
00:01:27 All intelligence is collective intelligence
00:03:45 Main points of the talk
00:04:32 Single cell spatial competencies
00:06:19 Outline of the talk
00:06:46 PLASTICITY
00:08:18 Planarian memories survive brain regeneration
00:09:29 Tadpoles can see with artificially implanted eyes
00:10:42 Biological systems have competency in different scales and spaces
00:12:56 Planaria regenerates head with new adaptive gene expression
00:15:06 Technological Approach to Mind Everywhere
00:16:34 INTELLIGENT NAVIGATION IN MORPHOSPACE
00:16:34 Where are anatomy and shape encoded in biology?
00:17:55 Biomedical endgame: anatomical compiler
00:19:01 Unpredictability of anatomy of chimeric species: frogolotls
00:19:59 Hardware and software: analogy between nowadays biology and 40s-50s computer science
00:21:15 What is morphospace?
00:23:26 Examples of natural regeneration
00:25:15 Cells change molecular mechanisms to adapt shape to artifical constraints
00:27:05 Induced frog leg regenration takes different path than default limb development
00:28:08 Facial mispatterning in tadpoles still ends in normal frog faces
00:29:36 Feedback loops in pattern homeostasis and goal-directedness
00:31:34 BIOELECTRICITY
00:31:38 Usual example of bioelectricity explaining goal-directedness: the brain
00:32:49 Generalizing: non-brain tissues also encode goals through bioelectricity
00:34:36 Reading and writing electrical information in non-brain tissues
00:35:29 Reading #1: “electric face” before face development
00:36:45 Reading #2: electric signature before tumor development
00:37:12 Writing electrical information in non-brain tissues using neuroscience tools
00:38:12 Writing #1: inducing voltage patterns that develop organs and limbs
00:40:16 Writing #2: inducing limb regeneration
00:42:08 Writing #3: inducing anatomical memory that produces two-headed planaria when injured
00:47:01 Writing #4: inducing shape changes
00:48:36 Developing quantitative, predictive models
00:49:27 Writing #5: correcting brain defects using model predictions
00:51:14 Electroceutical drugs
00:52:09 TECHNOLOGICAL APPROACH TO MIND EVERYWHERE
00:52:18 Different scales of biological systems have different goals
00:55:00 Potential application to reverse cancer
00:55:48 Diversity of intelligences
00:57:16 Multi-scale control and up-scaling goals across spaces
00:59:01 Behavior of skin cells clusters when isolated: xenobots
01:07:15 Overview of the Technological Approach to Mind Everywhere
01:08:00 The space of intelligent agents and its implications for ethics
2 سال پیش
در تاریخ 1401/08/05 منتشر شده
است.
120,652
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