Mucosal Melanoma - Histopathology

Mucosal Melanoma - Histopathology, Head and Neck Pathology

-  Pleomorphic spindled and/or epithelioid cells infiltrating in sheets or loosely cohesive nests and cords
-  Melanin pigment is often present
-  An in situ component in the overlying mucosa may be observed
- Immunoprofile Description
Positive
   S100 (nuclear and cytoplasmic)
   S0X10 (nuclear)
   Melan A (cytoplasmic)
   HMB45 (cytoplasmic)
Negative
    Cytokeratins (location)

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