PMDD Linked to Gene Network

National Institutes of Health (NIH) researchers have discovered molecular mechanisms that may underlie a woman’s susceptibility to disabling irritability, sadness, and anxiety in the days leading up to her menstrual period. Such premenstrual dysphoric disorder (PMDD)  affects 2 to 5 percent of women of reproductive age, whereas less severe premenstrual syndrome (PMS)  is much more common.

“We found dysregulated expression in a suspect gene complex which adds to evidence that PMDD is a disorder of cellular response to estrogen and progesterone,” explained Peter Schmidt, M.D. of the NIH’s National Institute of Mental Health, Behavioral Endocrinology Branch. “Learning more about the role of this gene complex holds hope for improved treatment of such prevalent reproductive endocrine-related mood disorders.”

For more information see press release:
Sex Hormone–Sensitive Gene Complex Linked to Premenstrual Mood Disorder
https://www.nimh.nih.gov/news/science...

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