The super sepsis six

This video discusses the diagnostic and treatment processes that should be conducted within the first hour when a patient comes into a hospital with sepsis.

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This video is provided for general and educational information only. Please consult your health care provider for Information about your health.

This video was made by McMaster students Kirat Boparai, Breagh Cheng, Mankeeran Dhanoa and Anjali Periyalwar in collaboration with the McMaster Demystifying Medicine Program

Copyright McMaster University 2016

References:

Health Canada. Deaths Involving Sepsis in Canada, 2016.

Bone, C.; Balk, A.; Cerra, B.; Dellinger, P.; Fein, M.; Knaus, A.; Sibbald, J. Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis. Chest Journal. 1992, 101(6), 1644-1655.

Levy, M.; Fink, P.; Marshall, C.; Abraham, E.; Angus, D.; Cook, D.; Ramsay, G. 2001 International Sepsis Definitions Conference. Intensive care medicine. 2003, 29(4), 530-538.

Daniels, R.; Nutbeam, T.; McNamara, G.; Galvin, C. The sepsis six and the severe sepsis resuscitation bundle: a prospective observational cohort study. Emergency Medicine Journal. 2011, 28(6), 507-512.

Daniels, R. (2011). Surviving the first hours in sepsis: getting the basics right (an intensivist's perspective). Journal of Antimicrobial Chemotherapy.  66 (2), ii11-ii23.

Chang, R., & Holcomb, J. B. (2016). Choice of Fluid Therapy in the Initial Management of Sepsis, Severe Sepsis, and Septic Shock. Shock (Augusta, Ga.).

Semler, M. W., & Rice, T. W. (2016). Sepsis Resuscitation: Fluid Choice and Dose. Clinics in Chest Medicine.

Chen, L. (2016). Don't Go Chasing Waterfalls: Excessive Fluid Resuscitation in Severe Sepsis and Septic Shock. Critical care nursing quarterly, 39(1), 34-37.

Gauer, R. L. (2013). Early recognition and management of sepsis in adults: the first six hours. American family physician, 88(1)

BMJ Best Practices. Sepsis in adults. http://bestpractice.bmj.com/best-prac...

Leone, M.; Bourgoin, A.; Cambon, S.; Dubuc, M.; Albanèse, J.; Martin, C. Empirical antimicrobial therapy of septic shock patients: adequacy and impact on the outcome. Critical Care Medicine. 2003, 31 (2), 462–467.

Leibovici, L.; Shraga, I.; Drucker, M.; Konigsberger, H.; Samra, Z.; Pitlik, S. D. J. The benefit of appropriate empirical antibiotic treatment in patients with bloodstream infection. Journal of Internal Medicine. 1998, 244, 379 - 386.

Garnacho-Montero, J.; Garcia-Garmendia, J. L.; Barrero-Almodovar, A.; Jimenez-Jimenez, F. J.; Perez-Paredes, C.; Ortiz-Leyba, C. Impact of adequate empirical antibiotic therapy on the outcome of patients admitted to the intensive care unit with sepsis. Critical Care Medicine. 2003, 31 (12), 2742 - 2751.

Bochud, P.-Y.; Bonten, M.; Marchetti, O.; Calandra, T. Antimicrobial therapy for patients with severe sepsis and septic shock: an evidence-based review. Critical Care Medicine. 2004, 32 (11), S495 - S512.

Green RS, Djogovic D, Gray S, Howes D, Brindley PG, Stenstrom R, Patterson E, Easton D, Davidow JS; CAEP Critical Care Interest Group. Canadian Association of Emergency Physicians Sepsis Guidelines: the optimal management of severe sepsis in Canadian emergency departments. Canadian Journal of Emergency Medicine. 2008 Sep;10(5):443-59.

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