Toxicology (Part-12) Morphine Poisoning Cause, Symptoms, Diagnosis & Treatment | Morphine Poisoning

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Toxicology is a scientific discipline, overlapping with biology, chemistry, pharmacology, and medicine, that involves the study of the adverse effects of chemical substances on living organisms and the practice of diagnosing and treating exposures to toxins and toxicants. The relationship between dose and its effects on the exposed organism is of high significance in toxicology. Factors that influence chemical toxicity include the dosage, duration of exposure (whether it is acute or chronic), route of exposure, species, age, sex, and environment. Toxicology is a field of science that helps us understand the harmful effects that chemicals, substances, or situations, can have on people, animals, and the environment. Some refer to toxicology as the “Science of Safety” because as a field it has evolved from a science focused on studying poisons and adverse effects of chemical exposures, to a science devoted to studying safety.

Morphine is a very strong painkiller. It is one of a number of chemicals called opioids or opiates, which were originally derived from the poppy plant and used for pain relief or their calming effects. Morphine overdose occurs when a person intentionally or accidentally takes too much of the medicine.  For people struggling with morphine addiction and who have developed a level of tolerance, it often takes an increasingly higher dose of morphine to produce the same effects. Taking frequent high doses of morphine can significantly increase the chances of overdose.

The signs of morphine overdose are often noticeable changes in behavior and well-being. Morphine acts as a depressant on the central nervous system and the effects of a morphine overdose impact both the brain and body. While this can reduce pain and produce a calming effect, it can also have serious consequences if the dose of morphine is too high.

Some of the key symptoms of a morphine overdose are known as the ‘opioid overdose triad.’ These include:

(1) Slow and difficult breathing
(2) Loss of consciousness
(3) Very small pupils
Other side effects can include nausea, drowsiness, confusion or slurred speech. Someone who has taken too much morphine may seem tired or ‘out of it’ and may not be able to respond. The signs of a morphine overdose are serious and can be deadly. Recognizing these signs can help someone get treatment quickly, which can improve their prognosis. If you suspect that someone has overdosed on morphine, It’s important to call for help quickly.

Naloxone is an opioid antagonist medication used to block or reverse the effects of opioid drugs, particularly within the setting of drug overdoses which are rapidly becoming a leading cause of death worldwide. More specifically, naloxone has a high affinity for μ-opioid receptors, where it acts as an inverse agonist, causing the rapid removal of any other drugs bound to these receptors. When taken in large quantities, opioid medications such as morphine, hydromorphone, methadone, heroin, or fentanyl are capable of causing life-threatening symptoms such as respiratory depression, reduced heart rate, slurred speech, drowsiness, and constricted pupils. If untreated, this can progress to vomiting, absent pulse and breathing, loss of consciousness, and even death. Naloxone is indicated for the rapid reversal of these symptoms of central nervous system depression in opioid overdose. It's important to note that naloxone only works on opioid receptors within the body, and is therefore not capable of reversing the effects of non-opioid medications such as stimulants like methamphetamine or cocaine, or benzodiazepines like lorazepam or diazepam.

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