Fat Soluble Vitamin E (Tocopherol)

Clinical Biochemistry by Dr. P. K. Prabhakar
Clinical Biochemistry by Dr. P. K. Prabhakar
226 بار بازدید - 2 سال پیش - Fat-Soluble Vitamin EThere are two
Fat-Soluble Vitamin E
There are two types of vitamins, waters soluble vitamin and water-soluble vitamins, fat soluble vitamins, includes vitamin k, vitamin A, Vitamin D, and vitamin E. You can remember fat soluble vitamins as A, D, E and K.

Dietary sources, of vitamin E are, Vegetable oils, nuts, and green leafy vegetables.

500 IU, alpha-tocopherol per day, claim inhibition of lipid oxidation in atherosclerotic lesions.

Vitamin E includes different groups of fat-soluble compounds and that are tocopherols and tocotrienols.

Tocopherols include:

✔️️ Alpha-Tocopherol
✔️️ Beta-Tocopherol
✔️️ Gamma-Tocopherol
✔️️ Delta-Tocopherol
Tocotrienols, also include alpha, beta, gamma, and delta forms. Alpha-form of tocopherol is the most active one, this alpha form, consists of 6-hydroxy, chromane ring with isoprenoid side chain. Antioxidant property, of vitamin E is due OH on this chromane ring.

To understand their structure, watch a video on Vitamin E.

Vitamin E Antioxidant
Vitamin E prevents lipid peroxidation, this process involves three steps:

Initiation
Propagation
Termination
These steps involve different compound, these are as following:

Polyunsaturated fatty acids
Hydroxyl radical
Lipid peroxyl radical
Lipid peroxide
To understand these steps and role of vitamin E in lipid peroxidation watch our video on vitamin E.

Alpha-tocopherol is a secondary or a chain breaking antioxidant, it inhibits propagative phase.

Vitamin E Toxicity
Few toxic effects have been reported, however high doses might cause increased clotting times in subjects with a low vitamin K status.

Vitamin E Deficiency Diseases
Vitamin E Deficiency occurs in following:

✔️ Children with cystic fibrosis.

✔️ Patients with steatorrhea.
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2 سال پیش در تاریخ 1401/10/07 منتشر شده است.
226 بـار بازدید شده
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