Glycogenesis made easy: Definition ll Site ll Pathway ll Significance ll Regulation
63.1 هزار بار بازدید -
4 سال پیش
-
This video is about :Glycogenesis
This video is about :
Glycogenesis
Glycogenesis Definition
Glycogenesis Location
Glycogenesis Pathway
Glycogenesis Significance
Glycogenesis Regulation.
Glycogen metabolism in biochemistry
Glucose storage
Liver glycogen
Glycogen synthesis
Muscle glycogen
Carbohydrate metabolism
Glucose polymerization
Glycogenin
Enzymes involved in glycogenesis
Glycogen branching enzyme
Liver gluconeogenesis
Glycogen granules
Insulin regulation
Glycogen phosphorylase
Amylopectin
Glucose-6-phosphate
Glycogen synthase
Glycogenic hormones
Endocrine signaling
Energy reserve
Homeostatic mechanism
Glycogenesis is the process of glycogen synthesis, in which glucose molecules are converted and stored as glycogen for energy storage in cells, particularly in the liver and muscle tissue. Here is a step-by-step overview of the glycogenesis process:
1. Glucose uptake: Glucose is transported into the liver or muscle cells through glucose transporters, such as GLUT2 in the liver and GLUT4 in muscle cells. This allows glucose to enter the cells and serve as a substrate for glycogen synthesis.
2. Conversion to glucose-6-phosphate: Once inside the cells, glucose is converted to glucose-6-phosphate (G6P) by the enzyme hexokinase. This step traps glucose within the cells, as G6P cannot easily exit through the glucose transporters.
3. Conversion to glucose-1-phosphate: G6P is then converted to glucose-1-phosphate (G1P) by the enzyme phosphoglucomutase.
4. Activation of G1P: G1P is activated by the addition of a nucleotide, uridine triphosphate (UTP), to form UDP-glucose (uridine diphosphate glucose). This reaction is catalyzed by the enzyme UDP-glucose pyrophosphorylase.
5. Formation of glycogen primer: Glycogenin, a protein enzyme, acts as a primer for glycogen synthesis. It catalyzes the addition of several glucose molecules to itself, forming a short chain of about 8 glucose units linked by α-1,4-glycosidic bonds.
6. Elongation of glycogen chains: Glycogen synthase is the main enzyme responsible for elongating the glycogen chains. It adds additional glucose units to the growing glycogen molecule by forming α-1,4-glycosidic bonds between the glucose molecules.
7. Branching of glycogen: As the glycogen chains grow, branching occurs to increase the storage capacity and accessibility of stored glucose. Branching is achieved by the enzyme branching enzyme (glycogen branching enzyme), which transfers a portion of the glycogen chain to a new site by creating an α-1,6-glycosidic bond. This branching enzyme forms branches at approximately every 10 glucose units.
8. Continued elongation and branching: The elongation and branching steps continue, resulting in the formation of a highly branched glycogen structure.
Overall, glycogenesis is a complex process involving multiple enzymatic steps to convert glucose into glycogen for storage. It provides a readily accessible form of stored energy that can be broken down and mobilized when needed, such as during periods of fasting or physical activity.
Join through this link @@biochemistryconcepts
#biology
#biochemistry
#carbohydratemetabolism
#glycogen
#glycogenesis
#glycogenmetabolism
#mbbs #bds
#physiotherapy
#bscbiotechnology
#bscbiology
#11th
#mscbiochemistry
#nursing
#easybiochemistry
Glycogenesis
Glycogenesis Definition
Glycogenesis Location
Glycogenesis Pathway
Glycogenesis Significance
Glycogenesis Regulation.
Glycogen metabolism in biochemistry
Glucose storage
Liver glycogen
Glycogen synthesis
Muscle glycogen
Carbohydrate metabolism
Glucose polymerization
Glycogenin
Enzymes involved in glycogenesis
Glycogen branching enzyme
Liver gluconeogenesis
Glycogen granules
Insulin regulation
Glycogen phosphorylase
Amylopectin
Glucose-6-phosphate
Glycogen synthase
Glycogenic hormones
Endocrine signaling
Energy reserve
Homeostatic mechanism
Glycogenesis is the process of glycogen synthesis, in which glucose molecules are converted and stored as glycogen for energy storage in cells, particularly in the liver and muscle tissue. Here is a step-by-step overview of the glycogenesis process:
1. Glucose uptake: Glucose is transported into the liver or muscle cells through glucose transporters, such as GLUT2 in the liver and GLUT4 in muscle cells. This allows glucose to enter the cells and serve as a substrate for glycogen synthesis.
2. Conversion to glucose-6-phosphate: Once inside the cells, glucose is converted to glucose-6-phosphate (G6P) by the enzyme hexokinase. This step traps glucose within the cells, as G6P cannot easily exit through the glucose transporters.
3. Conversion to glucose-1-phosphate: G6P is then converted to glucose-1-phosphate (G1P) by the enzyme phosphoglucomutase.
4. Activation of G1P: G1P is activated by the addition of a nucleotide, uridine triphosphate (UTP), to form UDP-glucose (uridine diphosphate glucose). This reaction is catalyzed by the enzyme UDP-glucose pyrophosphorylase.
5. Formation of glycogen primer: Glycogenin, a protein enzyme, acts as a primer for glycogen synthesis. It catalyzes the addition of several glucose molecules to itself, forming a short chain of about 8 glucose units linked by α-1,4-glycosidic bonds.
6. Elongation of glycogen chains: Glycogen synthase is the main enzyme responsible for elongating the glycogen chains. It adds additional glucose units to the growing glycogen molecule by forming α-1,4-glycosidic bonds between the glucose molecules.
7. Branching of glycogen: As the glycogen chains grow, branching occurs to increase the storage capacity and accessibility of stored glucose. Branching is achieved by the enzyme branching enzyme (glycogen branching enzyme), which transfers a portion of the glycogen chain to a new site by creating an α-1,6-glycosidic bond. This branching enzyme forms branches at approximately every 10 glucose units.
8. Continued elongation and branching: The elongation and branching steps continue, resulting in the formation of a highly branched glycogen structure.
Overall, glycogenesis is a complex process involving multiple enzymatic steps to convert glucose into glycogen for storage. It provides a readily accessible form of stored energy that can be broken down and mobilized when needed, such as during periods of fasting or physical activity.
Join through this link @@biochemistryconcepts
#biology
#biochemistry
#carbohydratemetabolism
#glycogen
#glycogenesis
#glycogenmetabolism
#mbbs #bds
#physiotherapy
#bscbiotechnology
#bscbiology
#11th
#mscbiochemistry
#nursing
#easybiochemistry
4 سال پیش
در تاریخ 1399/07/06 منتشر شده
است.
63,190
بـار بازدید شده