Morphine Induced Hyperglycemia and Analgesic Tolerance assessment | Protocol Preview
153 بار بازدید -
2 سال پیش
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Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities - a 2 minute Preview of the Experimental Protocol
Khadija Elhabazi, Safia Ayachi, Brigitte Ilien, Frédéric Simonin
Université de Strasbourg, Biotechnology and Cellular Signalling, UMR 7242 CNRS;
We describe a protocol to examine the development of opioid-induced hyperalgesia and tolerance in mice. Based on the measurement of thermal and mechanical nociceptive responses of naïve and morphine-treated animals, it allows to quantify the increase in pain sensitivity (hyperalgesia) and decrease in analgesia (tolerance) associated with chronic opiate administration.
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Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities - a 2 minute Preview of the Experimental Protocol
Khadija Elhabazi, Safia Ayachi, Brigitte Ilien, Frédéric Simonin
Université de Strasbourg, Biotechnology and Cellular Signalling, UMR 7242 CNRS;
We describe a protocol to examine the development of opioid-induced hyperalgesia and tolerance in mice. Based on the measurement of thermal and mechanical nociceptive responses of naïve and morphine-treated animals, it allows to quantify the increase in pain sensitivity (hyperalgesia) and decrease in analgesia (tolerance) associated with chronic opiate administration.
Visit https://www.jove.com?utm_source=youtube&utm_medium=social_global&utm_campaign=reseach-videos-2022 to explore our entire library of 14,000+ videos of laboratory methods and science concepts.
JoVE is the world-leading producer and provider of science videos with the mission to improve scientific research and education. Millions of scientists, educators, and students at 1500+ institutions worldwide, including schools like Harvard, MIT and Stanford benefit from using JoVE's extensive library of 14,000+ videos in their research,education and teaching.
Subscribe to our channel: jovejournalofvisualizedexperiments
2 سال پیش
در تاریخ 1401/06/24 منتشر شده
است.
153
بـار بازدید شده