Immunoglobulin gene switching | Heavy chain & Light chain gene rearrangement | Multiple gene model.
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The following video gives you an outline of the class switching of the Immunoglobulin gene during maturation. The p and n nucleotide arrangement in the RSS region and somatic hypermutation arise due to point mutation during N nucleotide rearrangement.
The junctional flexibility arises during the combinatorial joining of the V,D, and J chains, at the RSS region.
Combinatorial diversity in Humans:
– Heavy Chain: V (51), D (27), J (6) = 8262
– Light Chain: Kappa – V (40), J (5) = 200
Lambda – V(30), J (4) = 120
8262 x (200 x 120) = 2.64 x 106
For more details refer
https://www2.nau.edu/~fpm/immunology/...
If you want to have videos on any particular subject related to biotechnology, please write them down in the comment box.
The other biotechnology related videos on this channel are
@biotanime23
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Thankyou for watching the video and your support.
The following video gives you an outline of the class switching of the Immunoglobulin gene during maturation. The p and n nucleotide arrangement in the RSS region and somatic hypermutation arise due to point mutation during N nucleotide rearrangement.
The junctional flexibility arises during the combinatorial joining of the V,D, and J chains, at the RSS region.
Combinatorial diversity in Humans:
– Heavy Chain: V (51), D (27), J (6) = 8262
– Light Chain: Kappa – V (40), J (5) = 200
Lambda – V(30), J (4) = 120
8262 x (200 x 120) = 2.64 x 106
For more details refer
https://www2.nau.edu/~fpm/immunology/...
If you want to have videos on any particular subject related to biotechnology, please write them down in the comment box.
The other biotechnology related videos on this channel are
@biotanime23
agrobacterium | vectors.
DNA fingerprinting - principle,proced...
isolation of microorganisms, primary ...
Antigen processing and presentation| ...
T cell production and activation|Posi...
Complement system|Classical complemen...
Immune tolerance | Tolerance and tran...
Types of Immunoglobulin | Structure a...
For more videos subscribe to this channel.
Thankyou for watching the video and your support.
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در تاریخ 1401/11/30 منتشر شده
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