IP3 DAG pathway | G Protein Coupled Receptors (GPCR) |

IP3 DAG pathway is very important signaling pathway in cell signaling. Like cAMP pathway it also involves the functioning of GPCR. Following the ligand binding activation of GPCR, the alpha subunit of trimeric g-protein detatches from both trineri G protein and the receptor and then goes to bind the effector protein, here the effector molecule is the PLC  or the phospho lipase C enzyme.  The activated PLC acts on PIP2 and converts it tk two secondary messengers knkwn as IP3 nad DAG. DAG being a lipophilic molecule stays in the membrane and IP3 being a poloar molecule diffuses and bind to the Calcium channel present on the ER membrane and the calcium ions are released into the cytoplasm where the bind to the PKC and recruit the enzyme to the membrane. PKC on membrane is attacked by DAG and becomes active.

Links for the previous parts of this lecture series :
1st part cAMP pathway :
cAMP Pathway | G Protein Coupled Rece...
2nd part cAMP pathway

cAMP Pathway |G Protein Coupled Recep...

2. Introduction to cell signaling

Cell Signaling | Signal Transduction ...

3. Basic mechanism of cell signaling
Cell Signaling | Signal Transduction ...

4. Types of cell signaling

Autocrine, Paracrine And Endocrine si...

5. GPCR functioning mechanism
http://bit.ly/2OIrJ8v

6. PKA regulation of glycogen metabolism

Regulation of glycogen metabolism || ...

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