Hereditary Spherocytosis
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Hereditary spherocytosis (HS) is the
Hereditary spherocytosis (HS) is the most prevalent cause of hemolytic anemia due to an abnormal red cell membrane and classifies as a type of congenital hemolytic anemia. Oskar Minkowsky first described it in the early 1900s. Erythrocytes are unable to maintain their normal biconcave shape due to genetic mutations in membrane/cytoskeletal proteins that play a role in structural morphologic stability. Deficient or abnormal proteins may include spectrin, ankyrin, band 3, and band 4.2, encoded by different genes. The clinical manifestations vary based on the severity of disease and the type of genetic mutation.
Reference:
Zamora EA, Schaefer CA. Hereditary Spherocytosis. [Updated 2020 Jul 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NB...
Image credit: Kjpargeter, Stockking / Freepik @ http://www.freepik.com
https://pngtree.com/so/vector
https://pngtree.com/so/direction
https://pngtree.com/so/blood clipart
Murphree, S.. “A-PDF Split DEMO : Purchase from www.A-PDF.com to remove the watermark.” (2009).
Tang, Yu-Hang & Lu, Lu & Li, He & Evangelinos, Constantinos & Grinberg, Leopold & Sachdeva, Vipin & Karniadakis, George. (2017). OpenRBC: A Fast Simulator of Red Blood Cells at Protein Resolution. Biophysical Journal. 112. 10.1016/j.bpj.2017.04.020.
Das, Anirban & Bansal, Deepak. (2017). Non-immune Hemolytic anemia.
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Reference:
Zamora EA, Schaefer CA. Hereditary Spherocytosis. [Updated 2020 Jul 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NB...
Image credit: Kjpargeter, Stockking / Freepik @ http://www.freepik.com
https://pngtree.com/so/vector
https://pngtree.com/so/direction
https://pngtree.com/so/blood clipart
Murphree, S.. “A-PDF Split DEMO : Purchase from www.A-PDF.com to remove the watermark.” (2009).
Tang, Yu-Hang & Lu, Lu & Li, He & Evangelinos, Constantinos & Grinberg, Leopold & Sachdeva, Vipin & Karniadakis, George. (2017). OpenRBC: A Fast Simulator of Red Blood Cells at Protein Resolution. Biophysical Journal. 112. 10.1016/j.bpj.2017.04.020.
Das, Anirban & Bansal, Deepak. (2017). Non-immune Hemolytic anemia.
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4 سال پیش
در تاریخ 1399/07/25 منتشر شده
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