Topoisomerase 1 and 2 mechanism

Topoisomerase 1 and 2  - This lecture explains about the topoisomerase 1 and 2 mechanism of action. Topoisomerase 1 enzyme cleaves single strand of the DNA and can change the DNA linking number while the topoisomerase 2 can relax the DNA by creating negative supercoiling by cleaving both the DNA strands at the same time. This video lecture explains about the topoisomerase 1 mechanism and the topoisomerase 2 mechanism to relax the DNA by changing the DNA super coiling.


Type II topoisomerase cuts both strands of one DNA double helix, passes another unbroken DNA strand through it, and then reanneals the cut strand.
Both type 1 and type 2 topoisomerase are of 2 types.

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