From toads and sheep to chronotherapy: A melatonin story // Josephine Arendt
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6 سال پیش
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Josephine Arendt is the Emeritus
Josephine Arendt is the Emeritus Professor of Endocrinology at the University of Surrey, Emeritus Director of the Centre for Chronobiology, Doctor of Medicine Honoris Causa and Director of Stockgrand Ltd, a company that she founded in 1988 to exploit expertise in light and melatonin.
Professionally, she is a biochemist having completed her PhD on tryptophan, 5-hydroxytryptamine and related indoles at the University of London in 1966. She undertook post-doctoral studies at the University of Geneva, Switzerland from 1966-1977 studying the physiological role of the pineal hormone melatonin and of light in the organisation of seasonal and circadian rhythms. She returned to the UK in 1977 to take up her subsequent appointments.
She has pioneered immunotechnology for the detection and measurement of melatonin and its metabolites, their circadian and seasonal response to light, and their use to characterise circadian responses particularly in conditions such as jet lag and shift work. She first described the chronobiotic properties of melatonin in relation to human sleep and the circadian system and initiated its use for circadian rhythm related sleep disorders such as jet lag and non-24h sleep disorder of the blind. She highlighted the importance of light and melatonin in humans and for many years pursued research interests in this area including in Polar regions. In 1988 she founded a company Stockgrand Ltd, to exploit this expertise with all profits supporting research.
Professionally, she is a biochemist having completed her PhD on tryptophan, 5-hydroxytryptamine and related indoles at the University of London in 1966. She undertook post-doctoral studies at the University of Geneva, Switzerland from 1966-1977 studying the physiological role of the pineal hormone melatonin and of light in the organisation of seasonal and circadian rhythms. She returned to the UK in 1977 to take up her subsequent appointments.
She has pioneered immunotechnology for the detection and measurement of melatonin and its metabolites, their circadian and seasonal response to light, and their use to characterise circadian responses particularly in conditions such as jet lag and shift work. She first described the chronobiotic properties of melatonin in relation to human sleep and the circadian system and initiated its use for circadian rhythm related sleep disorders such as jet lag and non-24h sleep disorder of the blind. She highlighted the importance of light and melatonin in humans and for many years pursued research interests in this area including in Polar regions. In 1988 she founded a company Stockgrand Ltd, to exploit this expertise with all profits supporting research.
6 سال پیش
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