Driving on Interstate 95 across entire state of South Carolina

For the most part, the 198-mile (319 km) drive is fairly benign, passing through the pine forests, farmlands, and blackwater streams and swamps of the Coastal Plain. However, a few landmarks do exist to break up the monotony. Crossing from the south from Georgia just over the Savannah River bridge, motorists are greeted to an elaborate gateway into the state of South Carolina. The Juanita M. White Crosswalk also exists between exits 18 and 21.[2] A flyover on twin high-spans over Lake Marion provides an unexpected scenic break in the center of the highway's length. Moving further north and out of the Palmetto State, the NC state line is prominently marked by the South Of The Border amusement complex at the US 301/501 exit. Local traffic parallel to the interstate uses US 301 from South Of The Border to Santee, US 15 from Santee to Walterboro, and a combination of US 17 and US 17 Alt from Walterboro to the Georgia state line north of Savannah. In addition, Interstate 95 shares a number of concurrencies, or multiplexes, with three of these U.S. Routes at various stretches in South Carolina.

The old US 15-301 bridge runs along the west side of I-95 and is used for recreational purposes.