Huntington's Disease - Symptoms, mechanism, and treatment. Huntington's Chorea
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Huntington’s disease is a neurodegenerative
Huntington’s disease is a neurodegenerative disease.
Usually, Huntington’s symptoms usually starts from 30. And worse over time.
Eventually it is fatal, around after 20 years.
Huntington’s disease also called Huntington’s chorea.
Huntington’s Disease signs and symptoms include triad: Cognitive, motor, and Psychiatric Symptoms.
In 50 % of cases Psychiatric Symptoms appear first.
In the early stages minor personality changes can appear, problems in cognition, and physical skills, irritability and mood swings occur. These symptoms may go unnoticed.
Eventually will motor symptoms occur.
he most characteristic initial physical symptoms are jerky, random, and uncontrollable movements called chorea.
Chorea may be initially exhibited as general restlessness, small unintentionally initiated or uncompleted motions, lack of coordination, or slowed saccadic eye movements.
The clear appearance of symptoms such as rigidity, writhing motions, or abnormal posturing appear as the disorder progresses.
Common consequences are physical instability, abnormal facial expression, and difficulties chewing, swallowing, and speaking.
Sleep disturbances and weight loss are also associated symptoms. Eating difficulties commonly cause weight loss and may lead to malnutrition.
Cognitive abilities are progressively impaired and tend to generally decline into dementia.
The person looses abilities of logical thinking, planning, cognitive flexibility, abstract thinking and Inappropriate actions appear.
Reported neuropsychiatric signs are anxiety, depression, a reduced display of emotions, egocentrism, aggression, and compulsive behavior, the latter of which can cause or worsen addictions, including alcoholism, gambling, and hypersexuality.
Although Huntington’s disease commonly start after 30, it can start much earlier. Or much late.
Juvenile Huntington’s disease generally progresses at a faster rate with greater cognitive decline.
In Most Cases the disease it is inherited from parent and it has genetic basic.
The mechanism is mutation of Huntington’s Gene.
Which coding for Huntington protein. And this protein gradually damages brain cells.
Diagnosis of the onset of Huntington’s disease can be made following the appearance of physical symptoms specific to the disease.
Genetic testing can be used to confirm a physical diagnosis if no family history of HD exists.
No cure for HD is known, and full-time care is required in the later stages.
Treatments can relieve some symptoms, and in some, improve quality of life.
The best evidence for treatment of the movement problems is with tetrabenazine.
Huntington’s disease affects about 4 to 15 in 100,000 people of European descent
Usually, Huntington’s symptoms usually starts from 30. And worse over time.
Eventually it is fatal, around after 20 years.
Huntington’s disease also called Huntington’s chorea.
Huntington’s Disease signs and symptoms include triad: Cognitive, motor, and Psychiatric Symptoms.
In 50 % of cases Psychiatric Symptoms appear first.
In the early stages minor personality changes can appear, problems in cognition, and physical skills, irritability and mood swings occur. These symptoms may go unnoticed.
Eventually will motor symptoms occur.
he most characteristic initial physical symptoms are jerky, random, and uncontrollable movements called chorea.
Chorea may be initially exhibited as general restlessness, small unintentionally initiated or uncompleted motions, lack of coordination, or slowed saccadic eye movements.
The clear appearance of symptoms such as rigidity, writhing motions, or abnormal posturing appear as the disorder progresses.
Common consequences are physical instability, abnormal facial expression, and difficulties chewing, swallowing, and speaking.
Sleep disturbances and weight loss are also associated symptoms. Eating difficulties commonly cause weight loss and may lead to malnutrition.
Cognitive abilities are progressively impaired and tend to generally decline into dementia.
The person looses abilities of logical thinking, planning, cognitive flexibility, abstract thinking and Inappropriate actions appear.
Reported neuropsychiatric signs are anxiety, depression, a reduced display of emotions, egocentrism, aggression, and compulsive behavior, the latter of which can cause or worsen addictions, including alcoholism, gambling, and hypersexuality.
Although Huntington’s disease commonly start after 30, it can start much earlier. Or much late.
Juvenile Huntington’s disease generally progresses at a faster rate with greater cognitive decline.
In Most Cases the disease it is inherited from parent and it has genetic basic.
The mechanism is mutation of Huntington’s Gene.
Which coding for Huntington protein. And this protein gradually damages brain cells.
Diagnosis of the onset of Huntington’s disease can be made following the appearance of physical symptoms specific to the disease.
Genetic testing can be used to confirm a physical diagnosis if no family history of HD exists.
No cure for HD is known, and full-time care is required in the later stages.
Treatments can relieve some symptoms, and in some, improve quality of life.
The best evidence for treatment of the movement problems is with tetrabenazine.
Huntington’s disease affects about 4 to 15 in 100,000 people of European descent
2 سال پیش
در تاریخ 1401/08/08 منتشر شده
است.
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