Cyclooxygenase (COX) : Inflammation : Pathology
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𝐒𝐮𝐛𝐬𝐜𝐫𝐢𝐛𝐞 𝗙𝐨𝐫 𝗠𝐨𝐫𝐞 𝗜𝐧𝐟𝐨𝐫𝐦𝐚𝐭𝐢𝐨𝐧 𝐨𝐧
𝐒𝐮𝐛𝐬𝐜𝐫𝐢𝐛𝐞 𝗙𝐨𝐫 𝗠𝐨𝐫𝐞 𝗜𝐧𝐟𝐨𝐫𝐦𝐚𝐭𝐢𝐨𝐧 𝐨𝐧 𝗛𝐞𝐚𝐥𝐭𝐡 👩⚕ 𝐚𝐧𝐝 𝗠𝐞𝐝𝐢𝐜𝐢𝐧𝐞💉🩺💊
𝐘𝐨𝐮𝐭𝐮𝐛𝐞 : @medschoolsimplified007
📌𝗙𝗮𝗰𝗲𝗯𝗼𝗼𝗸 : Facebook: draishwaryakelkar
📌𝗧𝘄𝗶𝘁𝘁𝗲𝗿: Twitter: AishwayaDr
📌𝗜𝗻𝘀𝘁𝗮𝗴𝗿𝗮𝗺 : Instagram: clinical.learning
Cyclo Oxygenases : Inflammation : Pathology
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Cyclooxygenases (COX) are key enzymes in the inflammatory pathway, playing a crucial role in the synthesis of prostaglandins from arachidonic acid. There are two main isoforms: COX-1 and COX-2. COX-1 is constitutively expressed in most tissues and is involved in maintaining normal physiological functions such as gastric mucosal protection, platelet aggregation, and renal blood flow. In contrast, COX-2 is an inducible enzyme, primarily expressed at sites of inflammation in response to pro-inflammatory cytokines, growth factors, and other stimuli.
COX-1 and COX-2 in Inflammation
- COX-1: Produces prostaglandins that protect the stomach lining, regulate blood flow in the kidneys, and aid platelet function. Its role in inflammation is more supportive, maintaining homeostasis rather than promoting inflammation.
- COX-2: Upregulated during inflammatory responses, COX-2 generates prostaglandins that mediate inflammation, pain, and fever. These prostaglandins contribute to vasodilation, increased vascular permeability, and the sensitization of pain receptors.
Pathological Implications :
The overexpression of COX-2 in inflamed tissues leads to elevated levels of pro-inflammatory prostaglandins, exacerbating symptoms of inflammation such as pain, swelling, and redness. This pathway is targeted by nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin, ibuprofen, and selective COX-2 inhibitors (e.g., celecoxib), which reduce inflammation and alleviate pain by inhibiting COX activity.
Clinical Relevance
Understanding the roles of COX-1 and COX-2 is essential for developing effective anti-inflammatory therapies and managing inflammatory diseases. While inhibiting COX-2 can reduce inflammation and pain, inhibiting COX-1 can lead to side effects like gastrointestinal ulcers and impaired platelet function due to its protective roles.
#Cyclooxygenases #COX1 #COX2 #Inflammation #Pathology #FMGE #NEETPG #USMLE #MedicalStudents #Prostaglandins #NSAIDs #MedEd #StudyMedicine #HealthScience #MedicalExams #FutureDoctors #PainManagement #AntiInflammatory #LearnMedicine #Pharmacology
𝐘𝐨𝐮𝐭𝐮𝐛𝐞 : @medschoolsimplified007
📌𝗙𝗮𝗰𝗲𝗯𝗼𝗼𝗸 : Facebook: draishwaryakelkar
📌𝗧𝘄𝗶𝘁𝘁𝗲𝗿: Twitter: AishwayaDr
📌𝗜𝗻𝘀𝘁𝗮𝗴𝗿𝗮𝗺 : Instagram: clinical.learning
Cyclo Oxygenases : Inflammation : Pathology
---------------------------------------------------------------------------
Cyclooxygenases (COX) are key enzymes in the inflammatory pathway, playing a crucial role in the synthesis of prostaglandins from arachidonic acid. There are two main isoforms: COX-1 and COX-2. COX-1 is constitutively expressed in most tissues and is involved in maintaining normal physiological functions such as gastric mucosal protection, platelet aggregation, and renal blood flow. In contrast, COX-2 is an inducible enzyme, primarily expressed at sites of inflammation in response to pro-inflammatory cytokines, growth factors, and other stimuli.
COX-1 and COX-2 in Inflammation
- COX-1: Produces prostaglandins that protect the stomach lining, regulate blood flow in the kidneys, and aid platelet function. Its role in inflammation is more supportive, maintaining homeostasis rather than promoting inflammation.
- COX-2: Upregulated during inflammatory responses, COX-2 generates prostaglandins that mediate inflammation, pain, and fever. These prostaglandins contribute to vasodilation, increased vascular permeability, and the sensitization of pain receptors.
Pathological Implications :
The overexpression of COX-2 in inflamed tissues leads to elevated levels of pro-inflammatory prostaglandins, exacerbating symptoms of inflammation such as pain, swelling, and redness. This pathway is targeted by nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin, ibuprofen, and selective COX-2 inhibitors (e.g., celecoxib), which reduce inflammation and alleviate pain by inhibiting COX activity.
Clinical Relevance
Understanding the roles of COX-1 and COX-2 is essential for developing effective anti-inflammatory therapies and managing inflammatory diseases. While inhibiting COX-2 can reduce inflammation and pain, inhibiting COX-1 can lead to side effects like gastrointestinal ulcers and impaired platelet function due to its protective roles.
#Cyclooxygenases #COX1 #COX2 #Inflammation #Pathology #FMGE #NEETPG #USMLE #MedicalStudents #Prostaglandins #NSAIDs #MedEd #StudyMedicine #HealthScience #MedicalExams #FutureDoctors #PainManagement #AntiInflammatory #LearnMedicine #Pharmacology
3 ماه پیش
در تاریخ 1403/03/17 منتشر شده
است.
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