Sickle Cell Anemia Biochemistry || Sickle Cell Anemia
12.3 هزار بار بازدید -
4 سال پیش
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Biochemical Basis of Sickle Cell
Biochemical Basis of Sickle Cell Anemia - This is the video on sickle cell anemia with examples of theory questions and NEET PG MCQs.
00:00 - Introduction
00:37 - Examples of questions
01:04 - What is Sickle Cell Anemia?
01:37 - Biochemical Basis of Sickle Cell Anemia
02:20 - Pathophysiology of Sickle Cell Anemia
04:29 - Clinical Features of Sickle Cell Anemia
05:03 - Sickle Cell Crisis
05:47 - Sickle Cell Anemia and Sickle Cell Trait
06:13 - Sickle Cell Trait
06:59 - Sickle Cell Trait Offers Resistance to Malaria
08:08 - Diagnosis of Sickle Cell Anemia
08:53 - Electrophoresis in Sickle Cell Anemia
09:38 - Sickling Test
10:02 - Management of Sickle Cell Anemia
10:28 - NEET PG Biochemistry MCQs
Sickle Cell Anemia and Sickle Hemoglobin (Hbs)
Sickle cell anemia is a genetic disorder caused by production of an abnormal hemoglobin, known as sickle hemoglobin (HbS).
Production of HbS is due to mutation in the β-globin gene which codes for β globin chain.
The mutant β-globin chain of HbS has an altered amino acid sequence.
Glutamic acid residue normally present in the sixth position of β-chain of HbA is replaced by a valine residue as a result of mutation in the β -globin chain.
As polar (hydrophilic) glutamic acid residue is replaced by nonpolar (hydrophobic) valine, it generates hydrophobic contact point called, “Sticky patch”, on the outer surface of the β globin chain.
This alteration markedly reduces the solubility of deoxygenated HbS.
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00:00 - Introduction
00:37 - Examples of questions
01:04 - What is Sickle Cell Anemia?
01:37 - Biochemical Basis of Sickle Cell Anemia
02:20 - Pathophysiology of Sickle Cell Anemia
04:29 - Clinical Features of Sickle Cell Anemia
05:03 - Sickle Cell Crisis
05:47 - Sickle Cell Anemia and Sickle Cell Trait
06:13 - Sickle Cell Trait
06:59 - Sickle Cell Trait Offers Resistance to Malaria
08:08 - Diagnosis of Sickle Cell Anemia
08:53 - Electrophoresis in Sickle Cell Anemia
09:38 - Sickling Test
10:02 - Management of Sickle Cell Anemia
10:28 - NEET PG Biochemistry MCQs
Sickle Cell Anemia and Sickle Hemoglobin (Hbs)
Sickle cell anemia is a genetic disorder caused by production of an abnormal hemoglobin, known as sickle hemoglobin (HbS).
Production of HbS is due to mutation in the β-globin gene which codes for β globin chain.
The mutant β-globin chain of HbS has an altered amino acid sequence.
Glutamic acid residue normally present in the sixth position of β-chain of HbA is replaced by a valine residue as a result of mutation in the β -globin chain.
As polar (hydrophilic) glutamic acid residue is replaced by nonpolar (hydrophobic) valine, it generates hydrophobic contact point called, “Sticky patch”, on the outer surface of the β globin chain.
This alteration markedly reduces the solubility of deoxygenated HbS.
Subscribe my channel from - biochemistrybasicsbydramit
For more intersting stuffs related to biochemistry visit -
https://www.biochemistrybasics.com/
Follow me
On Twitter - Twitter: dr_biochemistry
On Instagram - Instagram: biochemisrybasics
On Facebook - Facebook: amit.v.m
#sicklecellanemia #HbS #biochemistry
4 سال پیش
در تاریخ 1399/07/18 منتشر شده
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