DNA major and minor grooves

My teaching project page: Biochemistry Literacy for Kids www.biochemistryliteracyforkids.com/ Proteins and other molecules that bind DNA specifically recognize either the major or minor groove. This is a short video that shows the differences between the major and minor grooves. Keep in mind that the chirality of the 1', 3', and 4' carbons of the deoxyribose confer asymmetry to the double helix and give rise to the major and minor groves.