Exploring SNRIs' Unique SERT and NAT Ratios - Why They Are Not All the Same!
2.4 هزار بار بازدید -
6 ماه پیش
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Embark on an enlightening journey
Embark on an enlightening journey through the nuanced landscape of Serotonin-Noradrenaline Reuptake Inhibitors (SNRIs), a class of medications used in the treatment of depression, anxiety, and chronic pain.
In this video, Dr Sanil Rege, Consultant Psychiatrist, goes beyond the surface to dissect the intricate mechanisms of SNRIs, revealing how they enhance cognition, affect emotions and alleviate pain by increasing the levels of serotonin and noradrenaline (norepinephrine) in the brain's synaptic cleft.
Key Moments:
0:00 Introduction to SNRIs
1:16 SNRI Effects on Dopaminergic and Noradrenergic Pathways
4:17 Why Desvenlafaxine and Duloxetine can help in severe forms of depression
4:43 Role of Noradrenaline in pain and its relevance to the choice of SNRI
5:22 Why does Venlafaxine have one of the most severe withdrawal symptoms?
However, not all SNRIs are the same. This analysis uncovers the distinct pharmacological profiles of venlafaxine, desvenlafaxine, duloxetine, milnacipran, and levomilnacipran, showcasing their varying affinities for serotonin (SERT) and noradrenaline (NAT) transporters.
These differences are not just chemical nuances; they have significant implications for clinical practice, influencing everything from dosing strategies to side effect management.
For instance, we explore how venlafaxine acts as an SSRI at lower doses and requires careful blood pressure monitoring at higher doses due to its potentiation of noradrenaline.
The video also sheds light on the role of SNRIs in pain management, particularly in conditions like fibromyalgia and diabetic neuropathy, where their ability to modulate noradrenaline levels offers substantial relief.
Furthermore, we address the challenges and considerations of SNRI withdrawal, comparing the nuances of venlafaxine and paroxetine withdrawal experiences due to their unique pharmacodynamic properties.
Join us as we navigate the complex but fascinating world of SNRIs, offering insights into their mechanisms, clinical applications, and the critical role they play in improving mental health and quality of life for individuals dealing with depression, anxiety, and chronic pain. This comprehensive guide is an invaluable resource for healthcare professionals, students, and anyone interested in the science behind these medications.
#SNRIsExplained #psychiatry #MentalHealthAwareness
#DepressionTreatment #AnxietyRelief
#ChronicPainManagement #SerotoninNoradrenaline #PharmacologyInsights #Venlafaxine #Duloxetine #Milnacipran #Levomilnacipran #MedicationEducation
#NeurotransmittersUnveiled
#PainReliefSolutions
#SNRIWithdrawal
🎓RESOURCES BY PSYCH SCENE:
🌐The Academy by Psych Scene: PSYCHIATRY EDUCATION REDEFINED
https://academy.psychscene.com/
Revolutionary psychiatry learning.
🌐Psych Scene Hub: PSYCHIATRY TEXTBOOK OF THE FUTURE
https://psychscenehub.com/
The Hub is devoted to making you a better mental health professional. Our team of academic and clinical experts bring you powerful summaries, videos and interviews in psychiatry and neurosciences.
🌐Psych Interview Online: REAL WORLD SKILLS FOR REAL WORLD SUCCESS
https://www.psychinterview.com/
The Psych Interview online courses offer high-quality training to help you improve your psychiatric interview skills through self-study. They are suitable for Psychiatrists, Psychiatry trainees, Mental health practitioners, Nurses and General Practitioners.
🌐Psych Scene Online: THE ONLINE COURSES TO HELP YOU SUCCEED
https://ranzcpexams.psychscene.com/
Learn at your own pace with the RANZCP Written Exam prep online courses, psychotherapy online courses and CEQ podcasts brought to you by the Psychiatry Training Experts.
🌐Psych Scene: THE PSYCHIATRY TRAINING EXPERTS
https://psychscene.com/
Psych Scene offers specialised training and professional development for Psychiatry Trainees, Psychiatrists, General Practitioners and Mental Health Practitioners. Here you can find our upcoming live courses.
--
📱SOCIALS
Subscribe for weekly videos on Psychiatry and Neuroscience:
Facebook: Facebook: PsychSceneHub
Instagram : Instagram: psychiatry.excellence
–
👋 LET’S CONNECT!
Follow Sanil Rege on LinkedIn: LinkedIn: sanilrege
In this video, Dr Sanil Rege, Consultant Psychiatrist, goes beyond the surface to dissect the intricate mechanisms of SNRIs, revealing how they enhance cognition, affect emotions and alleviate pain by increasing the levels of serotonin and noradrenaline (norepinephrine) in the brain's synaptic cleft.
Key Moments:
0:00 Introduction to SNRIs
1:16 SNRI Effects on Dopaminergic and Noradrenergic Pathways
4:17 Why Desvenlafaxine and Duloxetine can help in severe forms of depression
4:43 Role of Noradrenaline in pain and its relevance to the choice of SNRI
5:22 Why does Venlafaxine have one of the most severe withdrawal symptoms?
However, not all SNRIs are the same. This analysis uncovers the distinct pharmacological profiles of venlafaxine, desvenlafaxine, duloxetine, milnacipran, and levomilnacipran, showcasing their varying affinities for serotonin (SERT) and noradrenaline (NAT) transporters.
These differences are not just chemical nuances; they have significant implications for clinical practice, influencing everything from dosing strategies to side effect management.
For instance, we explore how venlafaxine acts as an SSRI at lower doses and requires careful blood pressure monitoring at higher doses due to its potentiation of noradrenaline.
The video also sheds light on the role of SNRIs in pain management, particularly in conditions like fibromyalgia and diabetic neuropathy, where their ability to modulate noradrenaline levels offers substantial relief.
Furthermore, we address the challenges and considerations of SNRI withdrawal, comparing the nuances of venlafaxine and paroxetine withdrawal experiences due to their unique pharmacodynamic properties.
Join us as we navigate the complex but fascinating world of SNRIs, offering insights into their mechanisms, clinical applications, and the critical role they play in improving mental health and quality of life for individuals dealing with depression, anxiety, and chronic pain. This comprehensive guide is an invaluable resource for healthcare professionals, students, and anyone interested in the science behind these medications.
#SNRIsExplained #psychiatry #MentalHealthAwareness
#DepressionTreatment #AnxietyRelief
#ChronicPainManagement #SerotoninNoradrenaline #PharmacologyInsights #Venlafaxine #Duloxetine #Milnacipran #Levomilnacipran #MedicationEducation
#NeurotransmittersUnveiled
#PainReliefSolutions
#SNRIWithdrawal
🎓RESOURCES BY PSYCH SCENE:
🌐The Academy by Psych Scene: PSYCHIATRY EDUCATION REDEFINED
https://academy.psychscene.com/
Revolutionary psychiatry learning.
🌐Psych Scene Hub: PSYCHIATRY TEXTBOOK OF THE FUTURE
https://psychscenehub.com/
The Hub is devoted to making you a better mental health professional. Our team of academic and clinical experts bring you powerful summaries, videos and interviews in psychiatry and neurosciences.
🌐Psych Interview Online: REAL WORLD SKILLS FOR REAL WORLD SUCCESS
https://www.psychinterview.com/
The Psych Interview online courses offer high-quality training to help you improve your psychiatric interview skills through self-study. They are suitable for Psychiatrists, Psychiatry trainees, Mental health practitioners, Nurses and General Practitioners.
🌐Psych Scene Online: THE ONLINE COURSES TO HELP YOU SUCCEED
https://ranzcpexams.psychscene.com/
Learn at your own pace with the RANZCP Written Exam prep online courses, psychotherapy online courses and CEQ podcasts brought to you by the Psychiatry Training Experts.
🌐Psych Scene: THE PSYCHIATRY TRAINING EXPERTS
https://psychscene.com/
Psych Scene offers specialised training and professional development for Psychiatry Trainees, Psychiatrists, General Practitioners and Mental Health Practitioners. Here you can find our upcoming live courses.
--
📱SOCIALS
Subscribe for weekly videos on Psychiatry and Neuroscience:
Facebook: Facebook: PsychSceneHub
Instagram : Instagram: psychiatry.excellence
–
👋 LET’S CONNECT!
Follow Sanil Rege on LinkedIn: LinkedIn: sanilrege
6 ماه پیش
در تاریخ 1402/11/21 منتشر شده
است.
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