One Carbon Metabolism | Tetrahydrofolate and the Folate Cycle

JJ Medicine
JJ Medicine
150.3 هزار بار بازدید - 6 سال پیش - Lesson on One Carbon Metabolism,
Lesson on One Carbon Metabolism, the role of tetrahydrofolate and the folate cycle. Tetrahydrofolate (THF) is derivative of folic acid (Vitamin B9), which is acquired from dietary sources. Tetrahydrofolate (THF) in various forms (N5,N10-methylene THF etc.) acts as a carbon donor, allowing cells to produce nucleic acids, amino acids and methionine and s-adenosyl methionine in the activated methyl cycle.

**Re-uploaded to correct mistake**

Hey guys! In this lesson you will learn about one carbon metabolism, tetrahydrofolate and its role in producing various cellular products needed for purine and pyrimidine synthesis. You will also learn which dietary sources contain folic acid (folate), how folate is processed to tetrahydrofolate, and you will also learn the enzymes of the pathway. The anti-cancer medications known as methotrexate and 5-fluorouracil and their enzyme targets will also be discussed. Finally, you will also learn how the one carbon metabolism pathway is connected with the activated methyl cycle and methionine metabolism.

Hope you all find it helpful.
JJ

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JJ
6 سال پیش در تاریخ 1397/04/15 منتشر شده است.
150,333 بـار بازدید شده
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